拉莫三嗪治疗双相障碍致罕见延迟皮疹1例
Rare Delayed Discovery Rash Caused by Lamotrigine in the Treatment of Bipolar Disorder: A Case Report
DOI: 10.12677/acm.2024.1451713, PDF,    科研立项经费支持
作者: 陈 红*, 谷瀚星, 孔伶俐#：青岛市精神卫生中心老年科，山东 青岛
关键词: 拉莫三嗪；双相情感障碍；皮疹；Lamotrigine； Bipolar Disorder； Rash
摘要: 1例69岁女性双相情感障碍患者，住院治疗过程中在服用拉莫三嗪超过8周后出现皮疹，且延迟发现1周，经过紧急停药及抗过敏处理后皮疹逐渐消失，血常规恢复正常。拉莫三嗪治疗双相情感障碍疗效较好，但皮疹发生率较高，有罕见病例在8周后才发生，易被忽视。
Abstract: A 69-year-old female patient with bipolar disorder developed a rash after taking lamotrigine for more than 8 weeks during hospitalization, and the rash was delayed for 1 week. After emergency withdrawal and anti-allergy treatment, the rash gradually disappeared and the blood routine returned to normal. Lamotrigine is effective in the treatment of bipolar disorder, but the incidence of rash is high. There are rare cases that occur after 8 weeks and are easy to be ignored.
文章引用：陈红, 谷瀚星, 孔伶俐. 拉莫三嗪治疗双相障碍致罕见延迟皮疹1例[J]. 临床医学进展, 2024, 14(5): 2509-2512. https://doi.org/10.12677/acm.2024.1451713

参考文献

[1] Ketter, T.A., Manji, H.K. and Post, R.M. (2003) Potential Mechanisms of Action of Lamotrigine in the Treatment of Bipolar Disorders. Journal of Clinical Psychopharmacology, 23, 484-495. [Google Scholar] [CrossRef] [PubMed]
[2] Mitchell, P., Hadzi-Pavlovic, D., Evoniuk, G., et al. (2013) A Factoranalytic Study in Bipolar Depression, and Response Tolamotrigine. CNS Spectrums, 18, 214-224. [Google Scholar] [CrossRef] 
[3] Geddes, J.R., Calabrese, J.J.R. and Goodwin, G.M. (2009) Lamotrigine for Treatment of Bipolar Depression: Independent Meta-Analysis and Meta-Regression of Individual Patient Data from Five Randomised Trials. British Journal of Psychiatry, 194, 4-9. [Google Scholar] [CrossRef] [PubMed]
[4] Robillard, M. and Conn, D.K. (2002) Lamotrigine Use in Geriatric Patients with Bipolar Depression. The Canadian Journal of Psychiatry, 47, 767-770. [Google Scholar] [CrossRef] [PubMed]
[5] Tournier, M., Neumann, A., Pambrun, E., et al. (2019) Conventional Mood Stabilizers and/or Second-Generation Antipsychotic Drugs in Bipolar Disorders: A Population-Based Comparison of Risk of Treatment Failure. Journal of Affective Disorders, 257, 412-420. [Google Scholar] [CrossRef] [PubMed]
[6] 邵盛春, 沈宏萍, 李孝容. 拉莫三嗪致Stevens-Johnson综合征1例[J]. 中国医院药学杂志, 2018, 38(17): 1874-1875.
[7] 高阳, 于爱平, 蒋玉凤, 等. HLA-B*1502等位基因与中国南方汉族癫痫患者拉莫三嗪皮肤不良反应关联性的Meta分析[J]. 中国医院药学杂志, 2016, 36(2): 110-114.
[8] 倪开济, 骆艳丽. 拉莫三嗪治疗双相情感障碍的研究进展[J]. 上海医药, 2014, 35(9): 20-23.
[9] 民福利, 李泽, 曾涛, 等. 汉族人群中芳香族抗癫痫药物所致交叉过敏反应与HLA-B*13:01基因型的相关性[J]. 中华神经医学杂志, 2021, 20(8): 799-804.
[10] Shi, Y.W., Min, F.L., Zhou, D., et al. (2017) HLA-A*2402 as a Common Risk Factor for Antiepileptic Drug-Induced Cutaneous Adverse Reactions. Neurology, 88, 2183-2191. [Google Scholar] [CrossRef] 
[11] Deng, Y.L., Li, S.P., Lin, Z.H., et al. (2018) Association between HLA Alleles and Lamotrigine-Induced Cutaneous Adverse Drug Reactions in Asian Populations: A Meta-Analysis. Seizure, 60, 163-171. [Google Scholar] [CrossRef] [PubMed]
[12] 赵亚铮, 李婷婷. 丙戊酸钠联合拉莫三嗪致中毒性表皮坏死松解症1例[J]. 医药导报, 2021, 40(12): 1752-1754.

为你推荐