神农益智解郁丸治疗脑卒中后抑郁的临床研究
Clinical Study on Shennong Yizhi Jieyu Pill in the Treatment of Post-Stroke Depression
摘要: 目的：探究神农益智解郁丸治疗脑卒中后抑郁的临床效果。方法：选用80例脑卒中后抑郁的患者，将其随机分为两组，各40例。对照组予以草酸艾司西酞普兰片、二级预防及心理疏导治疗，观察组在对照组的基础上加用神农益智解郁丸口服，疗程结束后比较两组HAMD评分、PSQI评分、NIHSS评分、Barthel指数。结果：治疗前，两组患者的HAMD评分、PSQI评分、NIHSS评分及Barthel指数无显著性变化(P > 0.05)，治疗后，观察组的HAMD评分、PSQI评分、NIHSS评分、Barthel指数均优于对照组(P < 0.05)。结论：神农益智解郁丸治疗脑卒中后抑郁有明显的临床疗效，它不仅可以有效改善患者的抑郁状况、睡眠质量，而且有利于患者神经功能缺损的恢复，并能提高卒中后抑郁患者的日常生活活动能力。
Abstract: Objective: To explore the clinical effect of Shennong Yizhi Jieyu Pill in the treatment of post-stroke depression. Methods: Eighty patients with post-stroke depression were randomly divided into two groups, with 40 patients in each group. The control group was treated with Escitalopram Oxalate Tablets, secondary prevention, and psychological counseling. The observation group was additionally administered Shennong Yizhi Jieyu Pill orally based on the control group’s treatment. After the course of treatment, the HAMD score, PSQI score, NIHSS score, and Barthel index were compared between the two groups. Results: Before treatment, there were no significant differences in HAMD score, PSQI score, NIHSS score, and Barthel index between the two groups (P > 0.05). After treatment, the observation group showed better outcomes in terms of HAMD score, PSQI score, NIHSS score, and Barthel index compared to the control group (P < 0.05). Conclusion: Shennong Yizhi Jieyu Pill has a significant clinical effect in the treatment of post-stroke depression. It can not only effectively improve patients’ depression and sleep quality but also facilitate the recovery of neurological deficits and enhance the daily living activities of patients with post-stroke depression.
文章引用：方丽, 张滨, 王祺, 马成, 左可方. 神农益智解郁丸治疗脑卒中后抑郁的临床研究[J]. 中医学, 2024, 13(5): 1141-1146. https://doi.org/10.12677/tcm.2024.135172

参考文献

[1] 徐格林, 刘新峰. 脑血管病介入治疗在中国的现状与展望[C]//中华医学会, 中华医学会神经病学分会. 第九次全国神经病学学术大会论文汇编. 2006: 1.
[2] 林莹莹, 黄年斌, 高敏, 等. 脑康颗粒治疗脑卒中后轻度认知功能障碍的临床观察[J]. 广州中医药大学学报, 2013, 30(4): 484-487.
[3] 安中平, 王艳, 王景华. 脑卒中后焦虑和抑郁障碍的影响因素分析[J]. 中国神经精神疾病杂志, 2010, 36(9): 562-564.
[4] 高霞, 高磊, 马钊, 等. 慢性期脑卒中患者抑郁状态的发生率及相关因素[J]. 中国康复医学杂志, 2012, 27(4): 339-343.
[5] 潘小平. 卒中后抑郁的发生与识别[J]. 中国卒中杂志, 2008, 3(9): 632-633.
[6] 刘永珍, 龙洁. 卒中后抑郁状态对预后的影响及治疗进展[J]. 国外医学(脑血管疾病分册), 2001, 9(4): 245-247.
[7] 何建阳, 徐艳, 江文仙. 脑卒中后焦虑抑郁的调查及心理干预研究[J]. 现代中西医结合杂志, 2007, 16(6): 815-816.
[8] 周春颜. 抑郁症及抑郁药物的合理应用[J]. 辽宁医学杂志, 2007, 21(3): 214-216.
[9] 许江虹, 李颖, 黄桢. 脑卒中后抑郁的中医药治疗进展[J]. 现代中西医结合杂志, 2011, 20(5): 641-643.
[10] 袁建新, 冯玉婧, 元小冬, 等. 脑供血动脉病变与脑卒中后早期抑郁的关系[J]. 广东医学, 2017, 38(z2): 61-63, 65.
[11] 刘喜艳, 甄微, 张钦聪, 等. 脑卒中后抑郁治疗与预防[J]. 中国老年学杂志, 2018, 38(4): 1010-1014.
[12] 童晓欣, 童萼塘. 抗抑郁药历史与研究进展[J]. 医药导报, 2009, 28(2): 135-139.
[13] 谢东浩, 蔡宝昌, 安益强, 等. 柴胡皂苷类化学成分及药理作用研究进展[J]. 南京中医药大学学报, 2007, 23(1): 63-65.
[14] Li, H.Y., Zhao, Y.H., Zeng, M.J., et al. (2017) Saikosaponin D Relieves Unpredictable Chronic Mild Stress Induced Depressive-Like Behavior in Rats: Involvement of HPA Axis and Hippocampal Neurogenesis. Psychopharmacology, 22, 3385-3394. [Google Scholar] [CrossRef] [PubMed]
[15] 吴丽, 王丽丽, 李伟, 等. 芍药苷和芍药内酯苷的抗抑郁作用与NO/cGMP信号转导通路的相关性[J]. 世界中医药, 2018, 13(7): 1714-1717, 1722.
[16] 王云. 枳壳芍药及吸收成分辛弗林和芍药苷抗抑郁促动力的多靶点机制[D]: [硕士学位论文]. 厦门: 厦门大学, 2017.
[17] Liu, Y.M., Hu, C.Y., Shen, J.D., et al. (2017) Elevation of Synaptic Protein Is Associated with the Antidepressant-Like Effects of Ferulic Acid in a Chronic Model of Depression. Physiology & Behavior, 169, 184-188. [Google Scholar] [CrossRef] [PubMed]
[18] 贾红梅, 唐策, 刘欢, 等. 基于网络药理学的香附抗抑郁作用机制研究[J]. 药物评价研究, 2019, 42(1): 49-55.
[19] 王秀云, 李云, 朱含笑, 等. 甘草苷对脑卒中后抑郁大鼠额前皮质脑源性神经营养因子及Bax和Bcl-2蛋白表达的影响[J]. 中华老年心脑血管病杂志, 2021, 23(6): 647-650.