基于“温阳活血”论治化疗后手足综合征

Treatment of Hand-Foot Syndrome after Chemotherapy Based on “Warming Yang and Promoting Blood Circulation”

摘要: 手足综合征(hand-foot syndrome, HFS)是化疗后常见的不良反应之一，现临床上未发现可明显改善其临床症状的有效方法。中医常把HFS归为“痹症”，其病因可分为两类，一类为外因，风寒湿三气侵袭合而为痹。另一类为内因，化疗药物性寒有毒，长时间的使用致阳气亏虚，抵御外邪无力，阻遏血液运行，日久生瘀。两类病因相互影响，又互为因果。基于上述论述，将补阳散寒，活血化瘀作为治疗HFS的大方向，两法结合，随证治之，既重视外邪之标，又兼顾阳虚血瘀之本。为临床中西医结合治疗HFS提供理论基础。通过案例介绍从温阳活血论治HFS的经验，以期为临床提供新思路、新方法。

Abstract: Hand-foot syndrome (HFS) is one of the common adverse reactions after chemotherapy, but there is no effective method to improve its clinical symptoms. Traditional Chinese medicine often classifies HFS as “arthralgia”, its etiology can be divided into two categories, one is external cause, wind, cold and dampness three qi invasion and combination caused by bi. The other is the internal cause, chemotherapy drugs are cold and toxic, long-term use of Yang qi deficiency, weak resistance to external evil, blocking blood movement, blood stasis after a while. The two kinds of causes affect each other, but also cause and effect each other. Based on the above discussion, supplementing Yang for dispelling cold and promoting blood stasis should be taken as the general direction of treatment of HFS. The combination of the two methods and the treatment with the syndrome should not only pay attention to the sign of external evil, but also take into account the root of Yang deficiency and blood stasis. It provides a theoretical basis for the clinical treatment of HFS by the combination of traditional Chinese and Western medicine. The experience of treating HFS by warming Yang and promoting blood circulation is introduced through cases, in order to provide new ideas and new methods for clinical treatment.