IL-12、IL-27和P53与卵巢上皮性肿瘤临床病理特征及预后的相关性研究

A Study on the Correlation between IL-12, IL-27 and P53 and Clinicopathological Features and Prognosis of Ovarian Epithelial Tumors

摘要: 目的：观察IL-12、IL-27、P53在卵巢癌组织、卵巢上皮性良性肿瘤组织、正常卵巢组织中的表达，探究其与卵巢上皮性肿瘤临床病理特征及预后的相关性。方法：免疫组化法检测IL-12、IL-27和P53在50例上皮性卵巢癌(上皮性卵巢癌(Epithelial Ovarian Cancer, EOC))、40例卵巢上皮性良性肿瘤及18例正常卵巢组织中的表达情况，探讨IL-12、IL-27和P53表达与EOC临床病理特征及预后的关系。结果：EOC中IL-12、IL-27和P53表达与FIGO分期、病理类型、组织分化程度有关(P < 0.05)，与年龄、淋巴结转移无关(P > 0.05)。IL-12、IL-27和P53在EOC中表达呈正相关(r = 0.364)。EOC中IL-12、IL-27和P53高表达与患者不良预后密切相关，IL-12、IL-27和P53高表达者的总生存期明显缩短(P < 0.05)。结论：IL-12、IL-27和P53可能参与EOC的发生、发展，有望作为EOC临床预后预测指标。

Abstract: Objective: To observe the expression of IL-12, IL-27 and P53 in ovarian cancer, epithelial benign tumor and normal ovarian tissue, and to explore their correlation with the clinicopathological features and prognosis of ovarian epithelial tumor. Methods: The expression of IL-12, IL-27 and P53 in 50 cases of EOC, 40 cases of ovarian epithelial benign tumor and 18 cases of normal ovarian tissue was detected by immunohistochemistry. The relationship between the expression of IL-12, IL-27 and P53 and the clinicopathological features and prognosis of EOC was investigated. Results: The expressions of IL-12, IL-27 and P53 in EOC were correlated with FIGO stage, pathological type and degree of tissue differentiation (P < 0.05), but not with age or lymph node metastasis (P > 0.05). The expression of IL-12, IL-27 and P53 in EOC was positively correlated (r = 0.364). The high expression of IL-12, IL-27 and P53 in EOC was closely associated with poor prognosis, and the overall survival of patients with high expression of IL-12, IL-27 and P53 was significantly shortened (P < 0.05). Conclusion: IL-12, IL-27 and P53 may be involved in the occurrence and development of EOC, and may be used as prognostic indicators of EOC.