老龄化影响下NF-κB通路对骨质疏松的双向调控研究
Bidirectional Regulation of Osteoporosis by the NF-κB Pathway under the Influence of Aging
DOI: 10.12677/ar.2024.113110, PDF,   
作者: 郑苗苗：上海理工大学健康科学与工程学院，上海
关键词: 骨质疏松；NF-κB通路；成骨细胞；破骨细胞；Osteoporosis； NF-κB Pathway； Osteoblast； Osteoclast
摘要: 随着世界人口的老龄化，骨质疏松症对健康的影响越来越大，给患者和社会造成了巨大的医疗、经济和家庭负担。该疾病以骨密度下降和骨骼微观结构退化为特征，极大地增加了老年群体骨折的危险性。核因子κB (NF-κB)信号通路在调控骨吸收与骨形成的过程中扮演了重要的角色，本文综述了NF-κB信号通路在骨质疏松症中的作用机制和调控路径，指出深入理解NF-κB通路的调节机制对于揭示骨质疏松症的发病机理、发展治疗策略和预防措施具有重要的意义。通过综合当前研究进展，本文旨在为骨质疏松症的治疗提供新的靶点和策略，促进相关疾病的预防和治疗研究。
Abstract: As the global population ages, the impact of osteoporosis on health is becoming increasingly significant, imposing substantial medical, economic, and familial burdens on patients and society. Characterized by a decline in bone density and deterioration of bone microarchitecture, this disease significantly raises the risk of fractures among the elderly. The nuclear factor κB (NF-κB) signaling pathway plays a crucial role in the regulation of bone resorption and formation. This paper reviews the mechanisms and regulatory pathways of the NF-κB signaling pathway in osteoporosis, highlighting the importance of understanding the regulatory mechanisms of the NF-κB pathway in uncovering the pathogenesis of osteoporosis, and in developing treatment strategies and preventive measures. By synthesizing current research progress, this paper aims to provide new targets and strategies for the treatment of osteoporosis, thereby advancing the research on prevention and treatment of related diseases.
文章引用：郑苗苗. 老龄化影响下NF-κB通路对骨质疏松的双向调控研究[J]. 老龄化研究, 2024, 11(3): 823-828. https://doi.org/10.12677/ar.2024.113110

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