羟基氯喹检测方法的进展研究

Progress Research on Hydroxychloroquine Detection Methods

摘要: 羟基氯喹被广泛认知为在治疗疟疾和系统性红斑狼疮过程中起重要作用。然而，随着羟基氯喹(HCQ)的不受控使用，其在环境中的含量的迅速增加可能对水生生物造成严重问题。研究表明，HCQ存在于正常海水生态系统中，并证实了其在植被和地下水中的高持久性和生物积累，为了对海水中羟基氯喹含量进行检测并对其作为污染物潜力的研究，我们需要开发一种用于定量和监测HCQ的传感器。随着技术的发展，人们使用了许多分析方法来检测，包括通过包括高效液相色谱法(HPLC)、电化学法、液相色谱–质谱法(LC-MS)、荧光和比色平台双模式光学检测等等。尽管如此，这些分析方法显示出各种困难。所以研究出一种方法，使其可以快速、灵敏、环保地检测出羟基氯喹成为了一个很值得研究的课题。

Abstract: Hydroxychloroquine is widely recognized as playing an important role in the treatment of malaria and systemic lupus erythematosus. However, with the uncontrolled use of hydroxychloroquine (HCQ), its rapid increase in levels in the environment may cause serious problems for aquatic life. Research shows that HCQ exists in normal seawater ecosystems and confirms its high persistence and bioaccumulation in vegetation and groundwater. In order to detect the content of hydroxychloroquine in seawater and study its potential as a pollutant, we need Development of a sensor for quantification and monitoring of HCQ. With the development of technology, many analytical methods have been used for detection, including high-performance liquid chromatography (HPLC), electrochemical methods, and liquid chromatography-mass spectrometry (LC-MS), fluorescence and colorimetric platforms and pattern optical detection and more. Nonetheless, these analytical methods display various difficulties. Therefore, developing a method that can detect hydroxychloroquine quickly, sensitively, and environmentally friendly has become a worthy research topic.