探讨中药单体冬凌草甲素对肺恶性肿瘤的影响

To Explore the Effect of Chinese Medicine Monomer Oridonin on Lung Malignant Tumor

摘要: 冬凌草甲素属于对映–贝壳杉烷型四环二萜类，是冬凌草的干燥地上部分提取物，具有抗菌、抗炎、抗肿瘤、抗病毒、抗氧化的作用。肺癌在全球癌症发病中占首位，位于男性发病率的第一位，女性肺癌的发病率仅次于乳腺癌居于第二。据统计，全球每年有130万人死于肺癌，我国肺癌发病率及死亡率，无论在农村还是城市，均位于第一位。目前肺癌的治疗方式包括手术治疗、化学治疗、免疫治疗和靶向治疗等，存在包括免疫损伤、骨髓抑制、脱发和厌食等一系列的副作用，对一些无法耐受手术及放化疗等抗肿瘤治疗手段的肺恶性肿瘤患者来说无疑是一种挑战。许多研究都证实了冬凌草甲素在抗肿瘤的治疗中有其明显药理作用以及在临床上也有广阔前景，且基本无毒副作用。本文对国内外冬凌草甲素相关文献进行查阅，探讨冬凌草甲素对肺恶性肿瘤的影响，以期为治疗肺恶性肿瘤提供新思路。

Abstract: Oridonin belongs to enantio-kaurane type tetracyclic diterpenoids. It is the dried aboveground part extract of Rabdosia rubesdoides, which has antibacterial, anti-inflammatory, anti-tumor, anti-virus and anti-oxidation effects. Lung cancer is the most common cancer in the world. It is the most common cancer in men and the second most common cancer in women. According to statistics, each year, 1.3 million people died of lung cancer, lung cancer incidence and mortality in China, in both the rural and urban, which both are located in the first place. At present, the treatment of lung cancer includes surgery, chemotherapy, immunotherapy and targeted therapy, etc. There are a series of side effects, including immune damage, bone marrow suppression, alopecia and anorexia. It is undoubtedly a challenge for some patients with lung cancer who cannot tolerate anti-tumor treatment such as surgery, radiotherapy and chemotherapy. Many studies have confirmed that oridonin has obvious pharmacological effects in anti-tumor treatment and has broad prospects in clinical practice, and basically has no toxic side effects. This article reviews the related literature of oridonin at home and abroad, and discusses the effect of oridonin on lung malignant tumors, in order to provide new ideas for the treatment of lung malignant tumors.