天山橐吾的化学成分研究

Studies on the Chemical Constituents of Ligularia narynensis

摘要: 天山橐吾(Ligularianarynensis)系橐吾属(Ligularia)菊科(Compositae)千里光族(Senecioneae Cass)。橐吾属植物含多种类型的萜类化合物，结构新颖、生物活性较强，为了挖掘更多的生物活性突出的橐吾属植物，开发新的中草药资源，本论文以采自我国新疆地区的天山橐吾为研究对象，对其全草进行系统的化学成分研究，使用¹H-NMR、¹³C-NMR、DEPT、¹H-¹HCOSY、HMBC、HSQC、NOESY等分析技术并且与相关文献数据比较鉴定了10个化合物的结构，主要包括倍半萜类、苯丙素类等化合物。为进一步研究天山橐吾的化学成分提供了一定的参考，也为下一步该植物的生物活性研究提供了一定的基础。

Abstract: Ligularia narynensis belongs to Ligularia Compositae Senecioneae Cass. Ligularia plants contain many types of terpenoids compounds with novel structures and strong bioactivities. In order to explore more Ligularia plants with outstanding bioactivities and to develop new resources of Chinese herbal medicine, the present thesis took Ligularia narynensis harvested from the Xinjiang region of China as the research object. By using analysis techniques such as ¹H-NMR, ¹³C-NMR, DEPT, ¹H-¹HCOSY, HMBC, HSQC, and NOESY, the structures of 10 compounds were identified and compared with relevant literature data. The compounds mainly include sesquiterpenes and phenylpropanoids, and other compounds. This work provides a certain reference for the further study of the chemical constituents of Ligularia narynensis and also lays a foundation for the subsequent research on the bioactivity of this plant.