小儿脓毒症高血糖机制及治疗研究进展

Research Progress on Mechanism and Treatment of Hyperglycemia in Children with Sepsis

摘要: 脓毒症是儿童常见的临床重症感染性疾病，其病情严重并发展快，可引起脓毒症休克和多器官功能衰竭，因此有较高的死亡率。脓毒症患儿通常伴有血糖升高，与体内代谢功能紊乱有关，因而高血糖为脓毒症患儿体内代谢功能失调的重要评价指标。脓毒症患儿血糖升高与应激状态、严重感染、胰岛素相对分泌不足以及胰腺功能受损有关。高血糖作为脓毒症患儿死亡的独立危险因素，不仅对患儿治疗和康复产生不良影响，严重时可导致患儿死亡，因此，对脓毒症伴高血糖患儿的血糖进行有效控制尤为重要。本文将从脓毒症患儿高血糖的发作机制、高血糖对脓毒症患儿的影响及胰岛素在高血糖中的应用等方面进行探究。

Abstract: Sepsis is a common clinical severe infectious disease in children, which is serious and develops rapidly, can cause septic shock and multiple organ failure, and has a high mortality. Children with sepsis are usually accompanied by elevated blood sugar, which is related to metabolic dysfunction in the body. Therefore, hyperglycemia is an important evaluation index of metabolic dysfunction in children with sepsis. Elevated blood sugar in children with sepsis is associated with stress, severe infection, relative insufficiency of insulin secretion, and impaired pancreatic function. As an independent risk factor for the death of children with sepsis, hyperglycemia not only has adverse effects on the treatment and rehabilitation of children with sepsis, but also can lead to death in severe cases. Therefore, it is particularly important to effectively control the blood sugar of children with sepsis and hyperglycemia. This paper will explore the attack mechanism of hyperglycemia in children with sepsis, the influence of hyperglycemia on children with sepsis, and the application of insulin in hyperglycemia.