计算化学在有机化学理论教学中的应用

Application of Calculational Chemistry in Organic Chemistry Education

摘要: 目的：研究旨在评估计算化学在有机化学理论教学改革中的应用效果。方法：文章以2022级药学专业学生为对象，将其分为两组：对照组采用传统教学方法，而实验组则采用融入计算化学的教学策略。结果：通过期末成绩分析和学生满意度调查，文章对教学改革的效果进行了评估。研究结果显示，实验组学生的有机化学期末成绩平均为73.94分，标准差为1.69分，显著高于对照组的68.17分，标准差为2.10分。两组间的成绩差异在统计学上具有显著性(P值为0.0157)。此外，教学满意度调查显示，实验组的学生满意度为96.4%，明显高于对照组的82.1%。结论：综上所述，引入计算化学的有机化学理论教学方法能显著提升学生对有机化学反应位点和机理的理解，进而提高学生的有机化学成绩及学习兴趣。

Abstract: Objective: To evaluate the impact of computational chemistry on the educational of organic chemistry. Methods: Grade 2022 students were bifurcated into two distinct groups for following study: one group followed the conventional educational paradigm, designated as the Control Group, while the other was immersed in a curriculum enriched with computational chemistry group. The efficacy of the educational approaches was assessed through a comprehensive evaluation process, which included both final examinations and a detailed questionnaire survey. Results: The computational chemistry group achieved a significantly higher final average score of 73.94 ± 1.69, as compared to the traditional group. A statistical analysis revealed a marked difference in the final scores between the two groups, with a P-value of 0.0157, indicating a significant disparity in educational outcomes when comparing the experimental group to the control. The experimental group demonstrated a higher level of satisfaction, with a reported rate of 96.4%, which surpasses that of the control group. Conclusion: Incorporating computational chemistry into the curriculum has been shown to markedly enhance students’ final scores in organic chemistry.