外泌体治疗糖尿病足溃疡方法探索

Exploration of Exosome Therapy for Diabetic Foot Ulcer

摘要: 背景：外泌体(Exosomes)，可由多种类型的细胞分泌的多泡内涵体，通过与细胞膜的融合将其中的递质转移到另一细胞，从而实现跨细胞信息传递并调节胞间信号传导，发挥多种生物学功能。外泌体在组织修复中具有优秀的效果。然而外泌体的临床应用也存在着一定的问题，一方面，靶向性不足；另一方面，外泌体外用存在效果不佳，失效的速度快的特点。在此，我们寻找到一种合适的载体对外泌体进行靶向增强以及延长作用时间。本文对我们所使用的研究方法进行简要阐述，以期为相关的研究提供一定的参考及借鉴。

Abstract: Background: Exosomes are multivesicular endosomes secreted by various types of cells, which transfer the transmitters to another cell through fusion with the cell membrane, thus achieving transcellular information transmission and regulating intercellular signal transduction, thus playing a variety of biological functions. Exosomes have excellent effects in tissue repair. However, there are some problems in the clinical application of exosomes. On the one hand, the targeting is insufficient; on the other hand, in vitro application of exotin has the characteristics of poor effect and fast failure rate. Here, we find a suitable vector for targeted enhancement of exosomes and prolonging the action time. This article briefly elaborates on the research methods we use, in order to provide some reference and inspiration for related research.