胰腺内分泌肿瘤的诊疗进展

Advances in Diagnosis and Treatment of Pancreatic Endocrine Tumors

摘要: 胰腺神经内分泌肿瘤(pancreatic neuroend ocrine tumors, pNETs)是一种主要来自神经内分泌细胞的肿瘤，具有异质性，复杂性的特点，且具有相对较好的预后及生物学行为。pNETs在所有胰腺肿瘤中占比较小，约1%~2%，近年来其发病率有所上升，影像学技术在提高检出率和分期准确性方面功能卓越，生物化学标志物也是诊断的重要补充工具，尤其在无法获得组织病理学确诊时起到关键作用。治疗方面，外科切除仍是早期pNETs的首选治疗方法，而非手术治疗领域的进展为晚期患者提供了更多选择。多学科综合治疗模式(MDT)正在推广，为患者提供个性化治疗方案。本综述介绍了pNETs在分类、临床表现、诊断和治疗方面的最新研究进展。未来，分子靶向治疗和个体化治疗策略将成为发展重点，为pNETs患者提供更精准、更有效的治疗。

Abstract: Pancreatic neuroendocrine tumors (pNETs) are neoplasms primarily arising from neuroendocrine cells, characterized by heterogeneity and complexity, yet exhibiting relatively favorable prognosis and biological behavior. pNETs account for a small proportion, approximately 1%~2%, of all pancreatic tumors, with an increasing incidence in recent years. Imaging techniques play a prominent role in enhancing detection rates and staging accuracy, while biochemical markers serve as important adjunctive tools in diagnosis, particularly when histopathological confirmation is unavailable. Surgical resection remains the preferred treatment for early-stage pNETs, while advancements in non-surgical treatments offer more options for advanced-stage patients. Multidisciplinary comprehensive treatment (MDT) is being promoted to provide personalized treatment plans for patients. This review outlines the latest research progress on the classification, clinical manifestations, diagnosis, and treatment of pNETs. In the future, molecular targeted therapy and personalized treatment strategies will be pivotal, offering more precise and effective treatments for pNETs patients.