基于生物信息学探究CXCL3在结肠腺癌中的临床价值

Exploration of the Clinical Value of CXCL3 in Colon Adenocarcinoma Based on Bioinformatics

摘要: 目的：通过生物信息学方法分析趋化因子CXCL3在结肠腺癌(Colon adenocircinoma, COAD)中的临床价值。方法：从TCGA数据库中提取出趋化因子CXCL3在COAD患者组织中的基因表达谱，通过R语言进行数据整理，并在COAD患者肿瘤组织与癌旁正常组织中进行差异表达分析，再对CXCL3进行相关性分析。为了进一步探讨CXCL3在COAD中可能参与的分子机制，通过DAVID平台展开CXCL3的功能富集分析，并呈现可视化结果，再结合临床病理因素分析，最后通过GEO外部数据库进行验证。结果：经分析发现CXCL3及其共表达基因集在肿瘤组织中高表达(p < 0.05)，且对患者生存有不良的潜在影响。结论：CXCL3基因结肠腺癌患者中高表达，对患者的预后有一定影响。

Abstract: Objective: To analyze the clinical value of chemokine CXCL3 in colon adenocarcinoma (COAD) by bioinformatics methods. Methods: The gene expression profile of chemokine CXCL3 in the tissues of COAD patients was extracted from the TCGA database, and the data were collated by R language, and the differential expression analysis was carried out in the tumor tissues of COAD patients and adjacent normal tissues, and then the correlation analysis of CXCL3 was carried out. To further explore the possible molecular mechanisms of CXCL3 involvement in COAD, the functional enrichment analysis of CXCL3 was expanded by the DAVID platform and the visual results were presented. After that, it was combined with clinic pathological factor analysis. Finally, it is verified through the GEO external database. Results: The analysis showed that CXCL3 and its co-expressed gene sets were highly expressed in tumor tissues (p < 0.05), and had a potential adverse effect on the survival of patients. Conclusion: The high expression of CXCL3 gene in patients with colon adenocarcinoma has a certain impact on the prognosis of patients.