血小板功能测定在冠心病发生血栓及出血中的研究进展及应用
Research Progress and Application of Platelet Function Measurement in the Occurrence of Thrombosis and Bleeding in Coronary Heart Disease
摘要: 冠状动脉疾病(coronary artery disease, CAD)已成为全球性老年人死亡率逐年增高的主要慢性疾病之一。冠心病中由血栓及出血性相关疾病引起的不良心血管事件发生率(major adverse cardiovascular events, MACE)也逐渐增加。抗血小板治疗可以有效减少冠心病(coronary heart disease, CHD)患者发生MACE的风险并降低死亡率。有效的血小板功能测定对临床抗血小板治疗具有重大的意义。一些随机临床试验对血小板功能测试指导临床决策的疗效既有阳性也有阴性结果。本综述简要描述当前血小板功能检测方法、抗血小板治疗的进展，探讨其临床实践意义，以期为做出个体化抗板治疗决策提供参考。
Abstract: Coronary artery disease (CAD) has become one of the main chronic diseases with increasing mortality rates among the global elderly. The incidence of major adverse cardiovascular events (MACE) caused by thrombosis and hemorrhagic related diseases in coronary heart disease is also gradually increasing. Antiplatelet therapy can effectively reduce coronary heart disease, the risk of developing MACE and reducing mortality in CHD patients. Effective platelet function testing is of great significance for clinical antiplatelet therapy. Some randomized clinical trials have both positive and negative results in guiding clinical decision-making through platelet function testing. This review briefly describes the current methods for platelet function testing and the progress of antiplatelet therapy, exploring their clinical significance, in order to provide reference for making personalized antiplatelet therapy decisions.
文章引用：李晓玲, 尹建国. 血小板功能测定在冠心病发生血栓及出血中的研究进展及应用[J]. 临床医学进展, 2024, 14(7): 372-379. https://doi.org/10.12677/acm.2024.1472024

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