泌尿系结石预防策略研究进展
Progress in the Study of Urinary Stone Prevention Strategies
DOI: 10.12677/acm.2024.1472064, PDF,   
作者: 胡细恒*:成都中医药大学医学与生命科学学院,四川 成都;杨 宇#:宜宾市第一人民医院泌尿外科,四川 宜宾
关键词: 泌尿系结石防治药物生活习惯Urinary Stones Prevention and Treatment Medication Lifestyle Habits
摘要: 泌尿系结石是一种常见的泌尿系统疾病,是指在泌尿系统内形成的固体结晶体沉积,临床上最为常见的是肾结石和输尿管结石,具体形成机制尚不明确,其形成可能与多种因素有关,目前的主流学说主要有肾钙化斑、过饱和结晶、抑制物缺乏学说、基质学说等几种学说。因其形成机制尚未明确,临床上无法根据结石的形成机制进行有效的预防措施及治疗方法,使得泌尿系结石的发病率和复发率居高不下。本文旨在探讨泌尿系结石的预防策略,包括生活及运动习惯、饮食习惯、液体摄入、药物防治等几方面。通过了解这些措施,有助于预防泌尿系结石,降低患病率及复发率,从而提高患者的生活质量及减少相关支出。
Abstract: Urinary stones are a common urinary system disease, refers to the formation of solid crystalline deposits in the urinary system, the most common clinical kidney stones and ureteral stones. The specific formation mechanism of urinary stones is still unclear, and their formation may be related to a variety of factors. Currently, the mainstream doctrines mainly include renal calcified plaque, supersaturated crystals, inhibitor deficiency, and stromal theory. The formation mechanism is not yet clear. The clinic cannot be based on the formation mechanism of the stone for effective preventive measures and treatment methods, which further makes the incidence of urinary stones and recurrence rate remains high. The purpose of this paper is to discuss the preventive strategies of urinary stones, including living and exercise habits, dietary habits, fluid intake, drug prevention and treatment, and other aspects. By understanding these measures, it will help to prevent urinary stones and reduce the prevalence and recurrence rates, thus improving the quality of life of patients and reducing related expenditures.
文章引用:胡细恒, 杨宇. 泌尿系结石预防策略研究进展[J]. 临床医学进展, 2024, 14(7): 653-660. https://doi.org/10.12677/acm.2024.1472064

参考文献

[1] Hoffman, A., Braun, M.M. and Khayat, M. (2021) Kidney Disease: Kidney Stones. FP Essentials, 509, 33-38.
[2] 张大军, 叶向东. 超微通道经皮肾镜术治疗难治性泌尿系结石[J]. 河南医学研究, 2021, 30(21): 4031-4034.
[3] Du, Y., Guo, B., Hu, H., Dong, Q., Li, Y., Zhang, J., et al. (2024) Association between Kidney Stones and Life’s Essential 8: A Population-Based Study. World Journal of Urology, 42, Article No. 274. [Google Scholar] [CrossRef] [PubMed]
[4] Gan, X., Zhou, C., He, P., Ye, Z., Liu, M., Yang, S., et al. (2023) Inverse Association of Glucosamine Use and Risk of New-Onset Kidney Stones in UK Adults with Less Sedentary Time. Preventive Medicine, 177, Article ID: 107738. [Google Scholar] [CrossRef] [PubMed]
[5] Liu, M., Wu, J., Gao, M., Li, Y., Xia, W., Zhang, Y., et al. (2023) Lifestyle Factors, Serum Parameters, Metabolic Comorbidities, and the Risk of Kidney Stones: A Mendelian Randomization Study. Frontiers in Endocrinology, 14, Article ID: 1240171. [Google Scholar] [CrossRef] [PubMed]
[6] Feng, X., Wu, W., Zhao, F., Xu, F., Han, D., Guo, X., et al. (2020) Association between Physical Activity and Kidney Stones Based on Dose-Response Analyses Using Restricted Cubic Splines. European Journal of Public Health, 30, 1206-1211. [Google Scholar] [CrossRef] [PubMed]
[7] Mao, W., Zhang, L., Sun, S., Wu, J., Zou, X., Zhang, G., et al. (2022) Physical Activity Reduces the Effect of High Body Mass Index on Kidney Stones in Diabetes Participants from the 2007-2018 NHANES Cycles: A Cross-Sectional Study. Frontiers in Public Health, 10, Article ID: 936552. [Google Scholar] [CrossRef] [PubMed]
[8] 陈增谋, 梁荣杰, 陈芬波, 等. 桂东地区258例泌尿系结石患者的结石成分与相关危险因素分析[J]. 临床泌尿外科杂志, 2017, 32(4): 286-289.
[9] Meriam, H., Kaaroud, H., Karray, R., Ben Hamida, F., Bouzid, K. and Abderrahim, E. (2024) Recurrent Urolithiasis Revealing Primary Hyperparathyroidism in a Nephrology Department. Case Reports in Nephrology, 2024, Article ID: 1265364. [Google Scholar] [CrossRef] [PubMed]
[10] Ali, Z., Rustandi, R., Sulchan, M., Birowo, P. and Winarni, T.I. (2023) Comparing the Risk Factors of Nephrolithiasis in Asian Countries Population: A Systematic Review and Meta-Analysis. Arab Journal of Urology, 22, 109-114. [Google Scholar] [CrossRef] [PubMed]
[11] Marić, I. (2019) Lifestyle Risk Factors and Bone Mass in Recurrent Stone-Forming Patients: A Cross-Sectional Study in 144 Subjects. Acta Clinica Croatica, 58, 439-445. [Google Scholar] [CrossRef] [PubMed]
[12] Wei, B., Tan, W., He, S., Yang, S., Gu, C. and Wang, S. (2024) Association between Drinking Status and Risk of Kidney Stones among United States Adults: NHANES 2007-2018. BMC Public Health, 24, Article No. 820. [Google Scholar] [CrossRef] [PubMed]
[13] Liu, M. and Park, S. (2022) A Causal Relationship between Alcohol Intake and Type 2 Diabetes Mellitus: A Two-Sample Mendelian Randomization Study. Nutrition, Metabolism and Cardiovascular Diseases, 32, 2865-2876. [Google Scholar] [CrossRef] [PubMed]
[14] Chong, B., Kong, G., Shankar, K., Chew, H.S.J., Lin, C., Goh, R., et al. (2023) The Global Syndemic of Metabolic Diseases in the Young Adult Population: A Consortium of Trends and Projections from the Global Burden of Disease 2000-2019. Metabolism, 141, Article ID: 155402. [Google Scholar] [CrossRef] [PubMed]
[15] Sakhaee, K. (2008) Nephrolithiasis as a Systemic Disorder. Current Opinion in Nephrology and Hypertension, 17, 304-309. [Google Scholar] [CrossRef] [PubMed]
[16] Prieto, R.M., Rodriguez, A., Sanchis, P., Morey, M., Fiol, M., Grases, F., et al. (2019) Association of Adherence to the Mediterranean Diet with Urinary Factors Favoring Renal Lithiasis: Cross-Sectional Study of Overweight Individuals with Metabolic Syndrome. Nutrients, 11, Article No. 1708. [Google Scholar] [CrossRef] [PubMed]
[17] Gan, X., Liu, M., He, P., Ye, Z., Xiang, H., Zhou, C., et al. (2024) Habitual Fish Oil Supplementation, Genetic Susceptibility of Kidney Stones and the Risk of New-Onset Kidney Stones. Journal of Clinical Lipidology, 18, e116-e124. [Google Scholar] [CrossRef] [PubMed]
[18] Jamshed, A. and Jabeen, Q. (2021) Prophylactic and Curative Potential of Peppermint Oil against Calcium Oxalate Kidney Stones. Pakistan Journal of Pharmaceutical Sciences, 34, 1867-1872.
[19] Demoulin, N., Aydin, S., Gillion, V., Morelle, J. and Jadoul, M. (2022) Pathophysiology and Management of Hyperoxaluria and Oxalate Nephropathy: A Review. American Journal of Kidney Diseases, 79, 717-727. [Google Scholar] [CrossRef] [PubMed]
[20] Huang, Y., Zhang, Y.H., Chi, Z.P., Huang, R., Huang, H., Liu, G., et al. (2019) The Handling of Oxalate in the Body and the Origin of Oxalate in Calcium Oxalate Stones. Urologia Internationalis, 104, 167-176. [Google Scholar] [CrossRef] [PubMed]
[21] Noonin, C. and Thongboonkerd, V. (2024) Beneficial Roles of Gastrointestinal and Urinary Microbiomes in Kidney Stone Prevention via Their Oxalate-Degrading Ability and Beyond. Microbiological Research, 282, Article ID: 127663. [Google Scholar] [CrossRef] [PubMed]
[22] Borghi, L., Schianchi, T., Meschi, T., Guerra, A., Allegri, F., Maggiore, U., et al. (2002) Comparison of Two Diets for the Prevention of Recurrent Stones in Idiopathic Hypercalciuria. New England Journal of Medicine, 346, 77-84. [Google Scholar] [CrossRef] [PubMed]
[23] 徐建强, 胡健, 刘川, 等. 饮食与泌尿系结石形成的相关性研究进展[J]. 重庆医学, 2022, 51(9): 1590-1595.
[24] 叶丹. 骨质疏松药物治疗的研究进展[J]. 牡丹江医学院学报, 2021, 42(1): 148-151.
[25] Holmes, R.P., Knight, J. and Assimos, D.G. (2015) Lowering Urinary Oxalate Excretion to Decrease Calcium Oxalate Stone Disease. Urolithiasis, 44, 27-32. [Google Scholar] [CrossRef] [PubMed]
[26] 方海琴, 姜萍, 王永俊, 等. 成人高尿酸血症与痛风食养指南(2024年版) [J]. 卫生研究, 2024, 53(3): 352-356.
[27] Karam, A., Mjaess, G., Younes, H. and Aoun, F. (2021) Increase in Urolithiasis Prevalence Due to Vitamins C and D Supplementation during the COVID-19 Pandemic. Journal of Public Health, 44, e625-e626. [Google Scholar] [CrossRef] [PubMed]
[28] Prier, M., Carr, A.C. and Baillie, N. (2018) No Reported Renal Stones with Intravenous Vitamin C Administration: A Prospective Case Series Study. Antioxidants, 7, Article No. 68. [Google Scholar] [CrossRef] [PubMed]
[29] Jiang, K., Tang, K., Liu, H., et al. (2019) Ascorbic Acid Supplements and Kidney Stones Incidence among Men and Women: A Systematic Review and Meta-Analysis. Urology Journal, 16, 115-120.
[30] Taylor, E.N. and Curhan, G.C. (2008) Determinants of 24-Hour Urinary Oxalate Excretion. Clinical Journal of the American Society of Nephrology, 3, 1453-1460. [Google Scholar] [CrossRef] [PubMed]
[31] Lin, Y., Zhou, C., Wu, Y., Chen, H., Xie, L. and Zheng, X. (2023) Mendelian Randomization Analysis Reveals Fresh Fruit Intake as a Protective Factor for Urolithiasis. Human Genomics, 17, Article No. 89. [Google Scholar] [CrossRef] [PubMed]
[32] Sakhaee, K., Maalouf, N.M. and Sinnott, B. (2012) Kidney Stones 2012: Pathogenesis, Diagnosis, and Management. The Journal of Clinical Endocrinology & Metabolism, 97, 1847-1860. [Google Scholar] [CrossRef] [PubMed]
[33] Touhami, M., Laroubi, A., Elhabazi, K., Loubna, F., Zrara, I., Eljahiri, Y., et al. (2007) Lemon Juice Has Protective Activity in a Rat Urolithiasis Model. BMC Urology, 7, Article No. 18. [Google Scholar] [CrossRef] [PubMed]
[34] Zhang, L., Li, S., Cong, M., Liu, Z., Dong, Z., Zhao, M., et al. (2023) Lemon-Derived Extracellular Vesicle-Like Nanoparticles Block the Progression of Kidney Stones by Antagonizing Endoplasmic Reticulum Stress in Renal Tubular Cells. Nano Letters, 23, 1555-1563. [Google Scholar] [CrossRef] [PubMed]
[35] Su, Y., Li, S., Li, X., Zhou, J., Chauhan, V.P., Li, M., et al. (2024) Tartronic Acid as a Potential Inhibitor of Pathological Calcium Oxalate Crystallization. Advanced Science, 11, Article ID: 2400642. [Google Scholar] [CrossRef] [PubMed]
[36] Liu, Y., Jin, X., Ma, Y., Sun, Q., Li, H. and Wang, K. (2022) Vinegar Reduced Renal Calcium Oxalate Stones by Regulating Acetate Metabolism in Gut Microbiota and Crystal Adhesion in Rats. International Urology and Nephrology, 54, 2485-2495. [Google Scholar] [CrossRef] [PubMed]
[37] Luo, D. and Xu, X. (2019) Vinegar Could Act by Gut Microbiome. eBioMedicine, 46, 30. [Google Scholar] [CrossRef] [PubMed]
[38] Zhu, W., Liu, Y., Lan, Y., Li, X., Luo, L., Duan, X., et al. (2019) Dietary Vinegar Prevents Kidney Stone Recurrence via Epigenetic Regulations. EBioMedicine, 45, 231-250. [Google Scholar] [CrossRef] [PubMed]
[39] Courbebaisse, M., Travers, S., Bouderlique, E., Michon-Colin, A., Daudon, M., De Mul, A., et al. (2023) Hydration for Adult Patients with Nephrolithiasis: Specificities and Current Recommendations. Nutrients, 15, Article No. 4885. [Google Scholar] [CrossRef] [PubMed]
[40] Lotan, Y., Buendia Jiménez, I., Lenoir-Wijnkoop, I., Daudon, M., Molinier, L., Tack, I., et al. (2013) Increased Water Intake as a Prevention Strategy for Recurrent Urolithiasis: Major Impact of Compliance on Cost-Effectiveness. Journal of Urology, 189, 935-939. [Google Scholar] [CrossRef] [PubMed]
[41] Wang, J., Chiang, H., Chen, H., Flores, M., Navas-Acien, A. and Kuo, C. (2022) Association of Water Intake and Hydration Status with Risk of Kidney Stone Formation Based on NHANES 2009-2012 Cycles. Public Health Nutrition, 25, 2403-2414. [Google Scholar] [CrossRef] [PubMed]
[42] Ferraro, P.M., Taylor, E.N., Gambaro, G. and Curhan, G.C. (2013) Soda and Other Beverages and the Risk of Kidney Stones. Clinical Journal of the American Society of Nephrology, 8, 1389-1395. [Google Scholar] [CrossRef] [PubMed]
[43] Zhao, J., Huang, Y. and Yu, X. (2022) Caffeine Intake and the Risk of Incident Kidney Stones: A Systematic Review and Meta-Analysis. International Urology and Nephrology, 54, 2457-2466. [Google Scholar] [CrossRef] [PubMed]
[44] Ferraro, P.M., Taylor, E.N., Gambaro, G. and Curhan, G.C. (2017) Dietary and Lifestyle Risk Factors Associated with Incident Kidney Stones in Men and Women. Journal of Urology, 198, 858-863. [Google Scholar] [CrossRef] [PubMed]
[45] Hollingsworth, J.M., Oerline, M.K., Hsi, R.S., Crivelli, J.J., Krampe, N., Asplin, J.R., et al. (2024) Real-World Effectiveness of Preventive Pharmacological Therapy in Patients with Urolithiasis: A Retrospective Cohort Study. American Journal of Kidney Diseases, 84, 83-93.e1. [Google Scholar] [CrossRef] [PubMed]
[46] Shahzadi, A., Ashfaq, U.A., Khurshid, M., Nisar, M.A., Syed, A. and Bahkali, A.H. (2024) Deciphering Multi-Target Pharmacological Mechanism of Cucurbita pepo Seeds against Kidney Stones: Network Pharmacology and Molecular Docking Approach. Current Pharmaceutical Design, 30, 295-309. [Google Scholar] [CrossRef] [PubMed]
[47] Chen, J., Wu, G., Zhu, L., Karrar, E. and Zhang, H. (2024) A Review of the Functional Activities of Chia Seed and the Mechanisms of Action Related to Molecular Targets. Food & Function, 15, 1158-1169. [Google Scholar] [CrossRef] [PubMed]
[48] Rashid, S., Sameti, M., Alqarni, M.H. and Abdel Bar, F.M. (2023) In Vivo Investigation of the Inhibitory Effect of Peganum harmala L. and Its Major Alkaloids on Ethylene Glycol-Induced Urolithiasis in Rats. Journal of Ethnopharmacology, 300, Article ID: 115752. [Google Scholar] [CrossRef] [PubMed]
[49] Nandhabalan, P., Ioannou, N., Meadows, C. and Wyncoll, D. (2018) Refractory Septic Shock: Our Pragmatic Approach. Critical Care, 22, Article No. 215. [Google Scholar] [CrossRef] [PubMed]
[50] Ferraro, P.M., Curhan, G.C., Gambaro, G. and Taylor, E.N. (2016) Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones. American Journal of Kidney Diseases, 67, 400-407. [Google Scholar] [CrossRef] [PubMed]
[51] Daudon, M., Frochot, V., Bazin, D. and Jungers, P. (2017) Drug-Induced Kidney Stones and Crystalline Nephropathy: Pathophysiology, Prevention and Treatment. Drugs, 78, 163-201. [Google Scholar] [CrossRef] [PubMed]
[52] Sasikumar, P., Gomathi, S., Anbazhagan, K., Abhishek, A., Paul, E., Vasudevan, V., et al. (2014) Recombinant Lactobacillus Plantarum Expressing and Secreting Heterologous Oxalate Decarboxylase Prevents Renal Calcium Oxalate Stone Deposition in Experimental Rats. Journal of Biomedical Science, 21, Article No. 86. [Google Scholar] [CrossRef] [PubMed]
[53] Wang, Z., Liu, L., Li, C., Zhao, Y., Tong, X., Cheng, X., et al. (2024) Carboxymethylated Rhizoma Alismatis Polysaccharides Reduces the Risk of Calcium Oxalate Stone Formation by Reducing Cellular Inflammation and Oxidative Stress. Urolithiasis, 52, Article No. 63. [Google Scholar] [CrossRef] [PubMed]
[54] Taheri, H., Feizabadi, M.M., Keikha, R. and Afkari, R. (2024) Therapeutic Effects of Probiotics and Herbal Medications on Oxalate Nephrolithiasis: A Mini Systematic Review. Iranian Journal of Microbiology. [Google Scholar] [CrossRef] [PubMed]