60例新生儿院内感染的临床分析

Clinical Analysis of 60 Cases of Neonatal Nosocomial Infection

摘要: 目的：分析新生儿院内感染的临床特征、病原菌及药物敏感情况，探讨新生儿院内感染的危险因素及用药，为其早期识别及处理提供参考。方法：对2018年1月1日至2024年1月1日青岛市市立医院新生儿重症监护病房(NICU)确诊的60例新生儿院内感染病例进行相关影响因素总结和分析。结果：新生儿院内感染以败血症感染为主，临床表现缺乏特异性；病原菌以革兰氏阴性菌为主；新生儿院内感染发生与胎龄、出生体重、侵袭性操作、长期静脉营养等高危因素有关。结论：新生儿院内感染缺乏特异性临床表现，应密切观察并动态监测，及时完善细菌培养及药敏试验，关注危险因素，早期诊治，改善预后。

Abstract: Objective: To analyze the clinical features, pathogenic bacteria and drug sensitivity of nosocomial infections in neonates, to explore the risk factors of nosocomial infections in neonates, and to provide reference for its early diagnosis and treatment. Methods: From Jan. 1st 2018 to Jan. 1st 2024, the incidence of 60 cases of neonatal nosocomial infections diagnosed in the neonatal intensive care unit (NICU) of Qingdao Municipal Hospital was summarized and analyzed. Results: Neonatal nosocomial infections were mainly sepsis infections, lack of specific clinical manifestations; pathogenic bacteria were mainly Gram-negative bacteria; high risk factors for neonatal nosocomial infections are related to gestational age, birth weight, invasive procedures, and long-term intravenous nutrition, etc. Conclusion: Neonatal nosocomial infections lack specific clinical manifestations. Close observation and dynamic monitoring should be carried out to improve bacterial culture and drug sensitivity tests in a timely manner, pay attention to risk factors, early diagnosis and treatment, and improve prognosis.