非酒精性脂肪肝合并结直肠息肉患者与TyG指数的相关性

Correlation between Non-Alcoholic Fatty Liver Disease with Colorectal Polyps and the Triglyceride-Glucose Index

摘要: 目的：分析非酒精性脂肪肝患者中甘油三酯–葡萄糖(TyG)指数作为结直肠息肉一个独立预测指标的有效性。方法：研究910名NAFLD患者，其中包括674例结直肠息肉患者和236例非结直肠息肉患者。采用最小绝对收缩和选择算子(LASSO)回归评估TyG指数与结直肠息肉风险的相关性。采用限制性立方样条(RCS)检验TyG指数与结直肠息肉的线性相关性。构建ROC曲线分析结直肠息肉的TyG指数预测值。结果：LASSO回归分析显示，TyG与结直肠息肉风险显著相关。RCS显示，在整个TyG指数范围内，结直肠息肉风险随TyG指数线性增加。此外，ROC曲线分析表明，TyG水平与传统危险因素相结合，提高了结直肠息肉的预测价值。结论：TyG指数有助于评估非酒精性脂肪肝患者发生结直肠息肉的风险。非酒精性脂肪肝和TyG指数升高的患者发生结直肠息肉的风险更高。因此，在管理NAFLD患者时，应评估TyG指数。

Abstract: Objective: To analyze the efficacy of the triglyceride-glucose (TyG) index as an independent predictive marker for colorectal polyps in patients with non-alcoholic fatty liver disease (NAFLD). Methods: The study involved 910 NAFLD patients, including 674 with colorectal polyps and 236 without. The least absolute shrinkage and selection operator (LASSO) regression was utilized to evaluate the correlation between the TyG index and the risk of colorectal polyps. A restricted cubic spline (RCS) test was employed to examine the linear relationship between the TyG index and colorectal polyps. Receiver operating characteristic (ROC) curve analysis was conducted to assess the predictive value of the TyG index for colorectal polyps. Results: LASSO regression analysis indicated a significant correlation between the TyG index and the risk of colorectal polyps. RCS demonstrated a linear increase in the risk of colorectal polyps across the entire range of the TyG index. Furthermore, ROC curve analysis showed that combining TyG levels with traditional risk factors enhanced the predictive value for colorectal polyps. Conclusion: The TyG index aids in assessing the risk of colorectal polyps in patients with non-alcoholic fatty liver disease. Patients with NAFLD and elevated TyG indices have a higher risk of developing colorectal polyps. Therefore, the TyG index should be evaluated in the management of NAFLD patients.