肺癌化疗后发生肺部感染的研究进展
Research Progress on Pulmonary Infection after Chemotherapy for Lung Cancer
DOI: 10.12677/acm.2024.1472109, PDF,   
作者: 史 锐*, 张彩莲：延安大学附属医院呼吸内科，陕西 延安
关键词: 肺癌；化疗；肺部感染；病原菌；危险因素；Lung Cancer； Chemotherapy； Pulmonary Infection； Pathogen； Risk Factors
摘要: 肺癌作为世界上发病率和死亡率最高的恶性肿瘤之一，至今仍然威胁着人类的生命健康。化疗作为肺癌最基础也是最重要的治疗方式，长期化疗会给患者机体抵抗力带来一定影响，增加其各种感染发生的可能性，尤其是肺部感染，影响患者治疗依从性以及预后，长期肺部感染可能会诱发脓毒症、呼吸衰竭甚至直接导致患者死亡。本文通过对肺癌患者化疗后发生肺部感染的发生机制、病原菌分布、耐药性、危险因素及预防策略进行阐述，进一步加强对于肺癌化疗后发生肺部感染的认识。
Abstract: Lung cancer, one of the most prevalent and deadly malignant tumors in the world, continues to threaten human life and health to this day. Chemotherapy is the most basic and important treatment method for lung cancer, but long-term chemotherapy can have an impact on the patient’s resistance, increasing the likelihood of various infections, especially pneumonia, affecting the patient’s adherence to treatment and prognosis. Long-term pneumonia may induce sepsis, respiratory failure, or even directly lead to the patient’s death. This article expounds on the mechanism of occurrence, distribution of pathogenic bacteria, drug resistance, risk factors, and prevention strategies of pneumonia in patients with lung cancer after chemotherapy, in order to further enhance understanding of pneumonia in patients with lung cancer after chemotherapy.
文章引用：史锐, 张彩莲. 肺癌化疗后发生肺部感染的研究进展[J]. 临床医学进展, 2024, 14(7): 1021-1026. https://doi.org/10.12677/acm.2024.1472109

参考文献

[1] Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[2] Chen, W.Q., Zuo, T.T., Zheng, R.S., et al. (2017) Lung Cancer Incidence and Mortality in China in 2013. Chinese Journal of Oncology, 39, 795-800.
[3] Dicato, M., Plawny, L. and Diederich, M. (2010) Anemia in Cancer. Annals of Oncology, 21, vii167-vii172. [Google Scholar] [CrossRef] [PubMed]
[4] 李鹏超, 冯谢宇. 桉柠蒎肠溶软胶囊联合哌拉西林他唑巴坦治疗晚期非小细胞肺癌化疗后伴肺部感染的临床疗效分析[J]. 癌症进展, 2020, 18(18): 1899-1902.
[5] 薛华, 魏胜全, 翟梅, 等. 脾多肽对晚期肺癌化疗患者肺部感染的疗效及免疫功能的影响[J]. 中华医院感染学杂志, 2020, 30(9): 1355-1359.
[6] Vento, S., Cainelli, F. and Temesgen, Z. (2008) Lung Infections after Cancer Chemotherapy. The Lancet Oncology, 9, 982-992. [Google Scholar] [CrossRef] [PubMed]
[7] Bao, Q.H., Zhou, H., Chen, X., et al. (2019) Characteristics and Influencing Factors of Pathogenic Bacteria in Lung Cancer Chemotherapy Combined with Nosocomial Pulmonary Infection. Chinese Journal of Lung Cancer, 22, 772-778.
[8] 刘翔, 胡陶玉, 李丹. 老年非小细胞肺癌患者放化疗院内感染的因素分析[J]. 西北药学杂志, 2023, 38(3): 200-204.
[9] 蒋爱民, 马宇彦, 刘娜, 等. 肺癌患者院内感染微生物学特点及预后因素分析[J]. 现代肿瘤医学, 2022, 30(9): 1598-1602.
[10] 蒋秀园, 李茂林, 吴文艳. 肺癌化疗患者感染的相关因素回顾性研究[J]. 系统医学, 2023, 8(1): 175-179.
[11] Belay, C.M., Zewale, T.A., Amlak, B.T., Abebe, T.G. and Hailu, G. (2022) Incidence and Predictors of Ventilator-Associated Pneumonia among Adult Intubated Patients in Bahir Dar Specialized Hospitals, 2021: A Retrospective Follow-Up Study. International Journal of General Medicine, 15, 8173-8182. [Google Scholar] [CrossRef] [PubMed]
[12] Wang, J.-Y., Wang, S.-S., Zhu, J., et al. (2022) Distribution and Drug Resistance of Respiratory Infection Pathogens in Patients with Lung Cancer after Chemotherapy. Laboratory Medicine, 37, 356-359. (In Chinese)
[13] Liu, Y. and Wang, Y. (2019) The Distribution of Pathogenic Bacteria in Lung Infection after Chemotherapy in Elderly Patients with Lung Cancer and Its Effect on Immune Function. Journal of Modern Oncology, 27, 233-236. (In Chinese)
[14] Liu, L.-B., Huang, G., Guo, S.-J., et al. (2017) Distribution of Pathogens Causing Pulmonary Infections in Patients with Advanced Lung Cancer after Chemotherapy and Influence on Immune Function. Chinese Journal of Nosoconmiology, 27, 5105-5108. (In Chinese)
[15] 刘治辉, 张国政. 124例肺癌患者放化疗后致肺部感染的病原菌分布及其耐药性分析[J]. 抗感染药学, 2021, 18(8): 1122-1126.
[16] 刘先忠, 杨晓宇, 邢海洋, 等. 肺癌放疗后继发肺部感染病原菌特点及呼吸指标、血清炎性因子水平变化分析[J]. 中国病原生物学杂志, 2024, 19(1): 65-69.
[17] 苏静静, 乐凌云, 田炳如, 等. 老年非小细胞肺癌患者放化疗医院感染病原菌与影响因素分析[J]. 中华医院感染学杂志, 2019, 29(4): 550-553.
[18] 蒋秀园, 李茂林, 吴文艳. 肺癌化疗患者感染的相关因素回顾性研究[J]. 系统医学, 2023, 8(1): 175-179.
[19] 陈书平. 老年晚期非小细胞肺癌患者化疗期间发生肺部真菌感染的相关影响因素分析[J]. 医学理论与实践, 2022, 35(5): 792-793.
[20] 李乔, 范习刚. 影响肺癌化疗患者发生肺部感染的危险因素分析[J]. 实用癌症杂志, 2020, 35(1): 85-87.
[21] 徐辉, 吴正霞, 张和平, 等. 晚期肺癌合并慢阻肺化疗后肺部感染的病原菌耐药情况及干预对策[J]. 中国肿瘤临床与康复, 2019, 26(7): 826-829.
[22] 宋洋, 夏冰, 吴岳光. 肺癌患者肺部感染的相关临床危险因素分析[J]. 中华全科医学, 2021, 19(3): 354-357.
[23] 金剑英, 朱延安, 郭群依, 等. 老年肺癌化疗患者合并肺部感染影响因素分析[J]. 浙江医学, 2018, 40(8): 817-819, 823.
[24] 谢双燕, 李思瑾, 李泽云, 等. 肺癌化疗患者发生肺部感染危险因素的Meta分析[J]. 中国现代医生, 2023, 61(34): 14-18.
[25] 王琴, 王丽华, 顾敏静, 等. 老年晚期非小细胞肺癌患者化疗期间肺部真菌感染的影响因素[J]. 中国老年学杂志, 2021, 41(9): 1987-1990.
[26] 李乔, 范习刚. 影响肺癌化疗患者发生肺部感染的危险因素分析[J]. 实用癌症杂志, 2020, 35(1): 85-87.
[27] 吴涛, 唐猛, 刘鸿翔. 老年肺癌化疗患者合并感染相关因素分析[J]. 中华医院感染学杂志, 2017, 27(17): 3875-3877.
[28] Londino, J.D., Lazrak, A., Collawn, J.F., Bebok, Z., Harrod, K.S. and Matalon, S. (2017) Influenza Virus Infection Alters Ion Channel Function of Airway and Alveolar Cells: Mechanisms and Physiological Sequelae. American Journal of Physiology-Lung Cellular and Molecular Physiology, 313, L845-L858. [Google Scholar] [CrossRef] [PubMed]
[29] Asano, F., Aoe, M., Ohsaki, Y., Okada, Y., Sasada, S., Sato, S., et al. (2012) Deaths and Complications Associated with Respiratory Endoscopy: A Survey by the Japan Society for Respiratory Endoscopy in 2010. Respirology, 17, 478-485. [Google Scholar] [CrossRef] [PubMed]
[30] Duruisseaux, M. and Esteller, M. (2018) Lung Cancer Epigenetics: From Knowledge to Applications. Seminars in Cancer Biology, 51, 116-128. [Google Scholar] [CrossRef] [PubMed]
[31] 袁丽. 肺癌合并院内肺部感染相关危险因素分析[J]. 中国社区医师, 2015, 31(32): 69-70+72.

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