高原低压低氧环境对急性胰腺炎微循环的影响

Effect of Low-Pressure, Low-Oxygen Environment in Plateau on Microcirculation in Acute Pancreatitis

摘要: 急性胰腺炎是一种临床常见的急腹症，病情复杂多变，病程轻重不等，重症者病死率高；急性胰腺炎发病机制复杂多变，其中微循环障碍对疾病的发生发展起着重要作用。虽然目前关于急性胰腺炎微循环障碍的研究取得了很大的进展，但既往多关注于平原常压常氧条件下，然而关于高原低压低氧环境下的研究较少；同时，近年来随着旅游业的发展，前往高海拔地区旅游或短期居住的人口也在逐年增加。本文结合国内外研究报道，对高原特殊环境下急性胰腺炎微循环障碍进行综述，旨在探讨高原低压低氧环境对急性胰腺炎微循环障碍的影响，以期为探索高原环境急性胰腺炎的发病机制及治疗提供新的思路。

Abstract: Acute pancreatitis is a common clinical acute abdominal disease, the condition is complex and variable, the course of the disease varies, and the mortality rate of severe cases is high. The pathogenesis of acute pancreatitis is complex and variable, in which microcirculatory disorders play an important role in the development of the disease. Although there has been a great deal of progress in the study of microcirculatory disorders in acute pancreatitis, much of the focus has been on normobaric and normoxic conditions in the plains, with fewer studies in low-pressure, low-oxygen environments in the highlands. However, in recent years, with the development of the tourism industry, the number of people travelling to high-altitude areas for tourism or short-term stays has also been increasing year by year. This paper reviews the microcirculatory disorders of acute pancreatitis in the special environment of plateau in conjunction with domestic and international research reports, aiming to explore the effect of low-pressure and low-oxygen environment of plateau on the microcirculatory disorders of acute pancreatitis, with a view to providing new ideas for exploring the pathogenesis and treatment of acute pancreatitis in the plateau environment.