阿尔兹海默病研究进展

Research Progress in Alzheimer’s Disease

摘要: 阿尔茨海默病(Alzheimer’s disease，简称AD)，一般被视为老年性痴呆的一种，在老年人群体中十分普遍，它是一种神经系统退化的疾病，主要影响65岁及以上的群体。在临床表现上，这种疾病主要表现为记忆丧失、语言障碍、行动能力下降、识别困难、空间定位能力受损、决策和执行能力下降，以及性格和行为的显著变化。自从AD被发现以来，大量的事实研究已经浮出水面，概述了该疾病的病因、分子机制和潜在的治疗方法，但尚未发现成功治愈该疾病的方法。这可能归因于AD的发病机制复杂，缺乏明确的分子机制，以及诊断资源和治疗的选择有限。本文就近年来关于阿尔兹海默病的病因、发病机制、临床症状及治疗策略作一综述，为进一步研究阿尔兹海默病提供理论依据。

Abstract: Alzheimer’s disease, abbreviated as AD, is generally regarded as a type of senile dementia and is very common in the elderly population. It is a neurodegenerative disease that mainly affects people aged 65 and above. In clinical manifestations, this disease is mainly characterized by memory loss, language disorders, decreased mobility, recognition difficulties, impaired spatial positioning ability, decreased decision-making and execution abilities, as well as significant changes in personality and behavior. Since the discovery of AD, a large amount of factual research has emerged, outlining the etiology, molecular mechanisms, and potential treatment methods of the disease, but no successful cure has been found yet. This may be attributed to the complex pathogenesis of AD, lack of clear molecular mechanisms, and limited diagnostic resources and treatment options. This article provides a review of the etiology, pathogenesis, clinical symptoms, and treatment strategies of Alzheimer’s disease in recent years, providing theoretical basis for further research on Alzheimer’s disease.