补肾疏肝中药治疗卵巢早衰临床疗效的Meta分析
Meta-Analysis of the Clinical Efficacy of Kidney Tonifying and Liver-Sparing Chinese Herbal Medicine in the Treatment of Premature Ovarian Failure
摘要: 目的：卵巢早衰(Premature Ovarian Failure, POF)是指女性在40岁之前出现的月经异常、雌激素水平紊乱、生育能力下降为主要临床表现的一种严重的生殖系统疾病。因此，本研究旨在评价补肾疏肝中药治疗卵巢早衰的疗效。研究方法：检索2017年1月1日至2022年12月31日的5个数据库。这些数据库包括PubMed、中国知网(CNKI)、维普数据库(VIP)、中国生物医学文献数据库(CBM)、万方数据库。收集了随机临床对照试验(RCT)，评估了补肾疏肝中药治疗卵巢早衰的效果。使用RevMan 5.4软件对总有效率、症状评分、月经改善率及不良反应发生率进行了Meta分析。共有9项RCT被纳入，涉及880名患者。Meta分析的结果表明：与西药相比，补肾疏肝中药在提高总有效率方面显著[相对风险(RR) = 1.24, 95%可信区间(CI) (1.14, 1.36), P = 0.99]。结论：补肾疏肝中药治疗POF安全有效，但由于纳入文献的质量及样本量低，还需要更多高质量、大样本的临床试验来进一步证实其疗效。
Abstract: Objective: Premature ovarian failure (POF) refers to a serious reproductive system disorder characterized by menstrual abnormalities, estrogen level disturbances, and decreased fertility primarily occurring before the age of 40 in females. Hence, this study aims to evaluate the efficacy of kidney-tonifying and liver-soothing Chinese herbal medicine in the treatment of POF. Methods: Five databases were searched from January 1, 2017, to December 31, 2022, including PubMed, China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals, China Biology Medicine disc (CBM), and Wanfang Database. Randomized controlled trials (RCTs) assessing the effects of kidney-tonifying and liver-soothing Chinese herbal medicine in the treatment of POF were collected. Meta-analysis using RevMan 5.4 software was conducted to evaluate the total effective rate, symptom scores, menstrual improvement rate, and incidence of adverse reactions. A total of 9 RCTs involving 880 patients were included. Meta-analysis results indicated that compared with Western medicine, kidney-tonifying and liver-soothing Chinese herbal medicine significantly improved the total effective rate [Relative Risk (RR) = 1.24, 95% Confidence Interval (CI) (1.14, 1.36), P = 0.99]. Conclusion: Kidney-tonifying and liver-soothing Chinese herbal medicine is safe and effective in the treatment of POF. However, due to the low quality and sample size of the included literature, more high-quality and large-sample clinical trials are needed to further confirm its efficacy.
文章引用：唐英, 蒲翔. 补肾疏肝中药治疗卵巢早衰临床疗效的Meta分析[J]. 中医学, 2024, 13(7): 1667-1673. https://doi.org/10.12677/tcm.2024.137256

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