超声脂肪指数(UDFF)对比MRI-PDFF、CAP诊断非酒精性脂肪肝的初步研究

A Preliminary Study of Ultrasound-Derived Fat Fraction (UDFF) Compared with MRI-PDFF and CAP in the Diagnosis of Nonalcoholic Fatty Liver Disease

摘要: 目的：探讨超声脂肪指数(UDFF)对比MRI质子密度脂肪分数(MRI-PDFF)、受控衰减参数(CAP)对非酒精性脂肪肝的脂肪含量测定的价值。方法：本研究选取126名受试者，其中46名进行UDFF和MRI-PDFF的测定，80名进行UDFF和CAP的测定。分析UDFF和MRI-PDFF，UDFF和CAP的一致性及相关性。结果：Bland-Altman分析显示肝脏S8段的UDFF值和MRI-PDFF值、UDFF值和CAP值在整体上具有良好的一致性。Spearman相关性分析显示肝脏S8段的UDFF值和MRI-PDFF值之间相关性较高(r = 0.721, P < 0.001)，UDFF值与CAP值之间相关性较高(r = 0.812, P < 0.001)。结论：使用UDFF测量肝脏脂肪变性与MRI-PDFF和CAP测量结果一致性强，表明UDFF在非酒精性脂肪肝的脂肪定量测定中具有较高的价值。

Abstract: Objective: To explore the diagnostic value of ultrasound-derived fat fraction (UDFF) compared with MRI proton-density fat fraction (MRI-PDFF) and controlled attenuation parameter (CAP) in the determination of fat content in nonalcoholic fatty liver. Methods: In this study, a total of 126 subjects were included, with 46 individuals undergoing measurements using UDFF and MRI-PDFF, and 80 individuals undergoing measurements using UDFF and CAP. The consistency and correlation between UDFF and MRI-PDFF, UDFF and CAP were analyzed. Results: Bland-Altman analysis showed that the UDFF values and MRI-PDFF values of liver S8 segment had good consistency with the UDFF values and CAP values on the whole. Spearman correlation analysis showed high correlation between S8 segment UDFF values and MRI-PDFF values (r = 0.721, P < 0.001), and high correlation between UDFF values and CAP values (r = 0.812, P < 0.001). Conclusion: The results of liver steatosis measured by UDFF were consistent with those measured by MRI-PDFF and CAP, indicating that UDFF has a high value in the quantitative determination of fat in nonalcoholic fatty liver.