伏诺拉生与奥美拉唑应用于胃食管反流病的疗效对比

Comparison of the Efficacy of Vonoprazan and Omeprazole in the Treatment of Gastroesophageal Reflux Disease

摘要: 目的：比较伏诺拉生和奥美拉唑在治疗胃食管反流病方面的临床疗效。方法：在2023年1月到2023年12月的时间段内，选取在荣成市人民医院治疗的84名胃食管反流病患者，随机分为观察组42人选用伏诺拉生片进行治疗，对照组42人选用奥美拉唑肠溶胶囊进行治疗，随后对两组的治疗效果进行了对比分析。结果：观察组的治疗总有效率明显高于对照组(95.24% vs. 85.71%, P < 0.05)；治疗结束后，与对照组相比，观察组的GerdQ量表分数显著较低，而SF-36量表分数则显著较高(P均 < 0.05)。此外，观察组的白细胞计数、C反应蛋白、白介素-6和降钙素原等指标在治疗结束后出现了较大幅度的下降，且这些差异具有统计学意义(P < 0.05)。关于不良反应方面，观察组的发生率为14.29% (6/42)，对照组为16.67% (7/42)，两组之间的差异无统计学意义(χ² = 0.091, P = 0.763)。结论：伏诺拉生片对胃食管反流病有较好的临床疗效，在改善患者生活质量的同时，能减轻患者的症状，降低炎症因子水平，安全性较好。

Abstract: Objective: To compare the clinical efficacy of vonoprazan and omeprazole in the treatment of gastroesophageal reflux disease. Methods: During the period from January 2023 to December 2023, 84 patients with gastroesophageal reflux disease treated in Rongcheng People’s Hospital were selected, 42 patients in the observation group were selected with vonoprazan tablets for treatment, and 42 patients in the control group chose omeprazole enteric capsules for treatment. Subsequently, the treatment effect of the two groups was compared. Results: The overall response rate in the observation group was significantly higher than that in the control group (95.24% vs. 85.71%, P < 0.05); after completion of treatment, the GerdQ scale score was significantly lower in the observation group, while the SF-36 scale was significantly higher (P < 0.05). In addition, the white blood cell count, C-reactive protein, interleukin-6, and procalcitonin in the observation group decreased significantly after the end of treatment, and these differences were statistically significant (P < 0.05). Regarding adverse reactions, the incidence was 14.29% (6/42) in the observation group and 16.67% (7/42) in the control group. There was no significant difference between the two groups (² = 0.091, P = 0.763). Conclusion: Vonoprazan has a good clinical effect on gastroesophageal reflux disease, can reduce the symptoms of patients, improve the quality of life of patients, reduce the level of inflammatory factors, and the safety is good.