基于数据挖掘浅析《叶氏女科证治》调经用药规律

Analysis of the Medication Rules for Regulating Menstruation in Diagnosis and Treatment of Ye’s Women’s Health Based on Data Mining

摘要: 目的：归纳《叶氏女科证治》调经方药，分析用药规律，为中医临床治疗月经病提供思路。方法：收集《叶氏女科证治》调经条目调经相关方剂，使用Excel表格建立本文原始数据库后进行数据清洗规范整理，并对根据纳排标准最终选纳的163首方剂的药物使用频次、药物功效及药物性、味、归经等数据进行统计；选用数据分析软件SPSS Modeler 18.0及SPSS Statistics 26对纳入方剂方药进行聚类分析及关联结果分析。结果：所录入药物中温性药物最多，占到用药总频次的33.66%；药味以辛味药为首，占到药物总使用频次的29.94%；以归脾(20.18%)及肝经(18.62%)药物最多；根据网络关联图分析得知，《叶氏女科证治》调经方剂核心药物组合是由熟地黄、当归、白芍、川芎组成的妇科第一方——四物汤。结论：《叶氏女科证治》在月经病的治疗中以补益气血、肝脾同治为要。

Abstract: Objective: To summarize the traditional Chinese medicine prescriptions for regulating menstruation in Diagnosis and Treatment of Ye’s Women’s Health, analyze the medication patterns, and provide ideas for the clinical treatment of menstrual diseases in traditional Chinese medicine. Method: Collect the relevant formulas for regulating menstruation in the Diagnosis and Treatment of Ye’s Women’s Health, use Excel spreadsheets to establish the original database of this article, and clean and organize the data in a standardized manner. Analyze the frequency of drug use, drug efficacy, drug properties, taste, and meridian distribution of 163 selected formulas according to the inclusion and exclusion standards; Cluster analysis and correlation analysis were performed on the included formulas using data analysis software SPSS Modeler 18.0 and SPSS Statistics 26. The results showed that the most commonly recorded drugs were warm, accounting for 33.66% of the total frequency of medication; The taste of the medicine is mainly spicy, accounting for 29.94% of the total frequency of drug use; The most common drugs were Guipi (20.18%) and Ganjing (18.62%); According to the analysis of the network correlation diagram, the core drug combination of the Diagnosis and Treatment of Ye’s Women’s Health regulating meridian formula is the first gynecological formula—Siwu Tang, which is composed of Rehmannia glutinosa, Angelica sinensis, White Peony, and Chuanxiong. Conclusion: In the treatment of menstrual disorders, the Diagnosis and Treatment of Ye’s Women’s Health emphasizes nourishing qi and blood, and treating liver and spleen simultaneously.