不同病因甲状腺毒症血常规炎性细胞相关性分析研究

Study on the Correlation Analysis of Blood Routine Inflammatory Cells in Different Causes of Thyrotoxicosis

摘要: 目的：观察分析血常规炎性细胞等相关指标与甲状腺毒症不同病因的相关性，并探讨其在临床中的意义。方法：选取2022年1月至2022年12月于同济大学附属东方医院胶州医院内分泌科门诊就诊的患者49例，包括27例Graves病患者(GD组)、22例桥本甲状腺炎患者(HT组)、以及在本院体检中心健康体检的志愿者30名(CON组)，比较三组间白细胞(WBC)、中性粒细胞(NC)、淋巴细胞(LC)、单核细胞(MC)、中性粒/淋巴细胞比值(NLR)、单核/淋巴细胞比值(MLR)等实验室资料及相关资料的差异。相关性分析甲状腺毒症不同病因与实验室检查指标的相关性。结果：HT组与CON组相比，WBC、LC、MLR均呈负相关(p < 0.05)，NC、NLR两组间均无相关性。GD组与CON组相比，NC、MC、NLR、MLR、FT3、FT4、TSH、TRAB均呈负相关(p < 0.05)，LC、WBC两组间均无相关性。HT组与GD组相比，WBC、LC、NC、MC、FT3、FT4、TSH、TRAB均呈负相关(p < 0.05)，MLR、NLR两组间均无相关性。结论：血常规为一种简单、廉价、临床应用广泛的临床检测指标，比较计算相关炎性指标有助于更好的指导临床桥本甲状腺炎和Graves病患者的鉴别诊断。

Abstract: Objective: To observe and analyze the correlation between blood routine inflammatory cells and different causes of thyrotoxicosis, and to explore its clinical significance. Methods: A total of 49 patients were selected from the endocrinology outpatient department of Jiaozhou Hospital, East Hospital Affiliated to Tongji University from January 2022 to December 2022, including 27 patients with Graves’ disease (GD group), 22 patients with Hashimoto thyroiditis (HT group), and 30 volunteers (CON group) who underwent physical examination in the physical examination center of our hospital. The laboratory data of leukocyte (WBC), neutrophil (NC), lymphocyte (LC), monocyte (MC), neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR) and other relevant data were compared between the three groups. The correlation between different etiology of thyrotoxicosis and laboratory test indexes was analyzed. Results: Compared with CON group, WBC, LC and MLR in HT group were negatively correlated (p < 0.05), while there was no correlation between NC and NLR groups. Compared with CON group, NC, MC, NLR, MLR, FT3, FT4, TSH and TRAB in GD group were all negatively correlated (p < 0.05), while no correlation was found between LC and WBC groups. Compared with GD group, WBC, LC, NC, MC, FT3, FT4, TSH and TRAB were all negatively correlated (p < 0.05), while MLR and NLR were not correlated. Conclusion: Blood routine is a simple, inexpensive and widely used clinical indicator, and comparative calculation of relevant inflammatory indicators is helpful to better guide the differential diagnosis of Hashimoto thyroiditis and Graves’ disease.