干燥综合征中西医发病机制及治疗研究进展
Research Progress on Pathogenesis and Treatment of Sjögren’s Syndrome with Traditional Chinese and Western Medicine
DOI: 10.12677/acm.2024.1482388, PDF,   
作者: 田莲巧:云南中医药大学第一临床医学院,云南 昆明;王 静*:云南省第一人民医院风湿免疫科,云南 昆明
关键词: 干燥综合征中医西医发病机制治疗Sjögren’s Syndrome Traditional Chinese Medicine Western Medicine Pathogenesis Treatment
摘要: 干燥综合征(Sjögren’s syndrome, SS)是一种以慢性炎症性损害为特征的自身免疫性疾病,主要影响唾液腺和泪腺功能,在中医学中归属于“燥痹”范畴。干燥综合征确切的病因及发病机制尚不明确,目前尚无根治方法,主要是缓解临床症状。本文就干燥综合征的中西医发病机制及治疗的研究进展综述如下,以期提高对疾病的认识,延缓病情,提高患者的生活质量。
Abstract: Sjögren’s syndrome (SS) is an autoimmune disease characterized by chronic inflammatory damage, which mainly affects the function of salivary glands and lacrimal glands, and belongs to the category of “dryness” in traditional Chinese medicine. The exact etiology and pathogenesis of Sjogren’s syndrome are not clear, and there is no radical cure at present, mainly to relieve clinical symptoms. This article reviews the research progress of the pathogenesis and treatment of Sjögren’s syndrome in traditional Chinese and Western medicine, in order to improve the understanding of the disease, delay the disease and improve the quality of life of patients.
文章引用:田莲巧, 王静. 干燥综合征中西医发病机制及治疗研究进展[J]. 临床医学进展, 2024, 14(8): 1537-1542. https://doi.org/10.12677/acm.2024.1482388

参考文献

[1] André, F. and Böckle, B.C. (2022) Sjögren’s Syndrome. JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 20, 980-1002. [Google Scholar] [CrossRef] [PubMed]
[2] 王钢, 漆文霞, 闫彦峰, 等. 中医药治疗干燥综合征的作用机制研究进展[J]. 中国实验方剂学杂志, 2021, 27(20): 227-235.
[3] Ramos-Casals, M., Brito-Zeron, P., Solans, R., Camps, M., Casanovas, A., Sopena, B., et al. (2013) Systemic Involvement in Primary Sjogren’s Syndrome Evaluated by the EULAR-SS Disease Activity Index: Analysis of 921 Spanish Patients (GEAS-SS Registry). Rheumatology, 53, 321-331. [Google Scholar] [CrossRef] [PubMed]
[4] 汤建平, 龚邦东. 干燥综合征的诊治现状、挑战和思考[J]. 诊断学理论与实践, 2022, 21(3): 291-298.
[5] Tian, Y., Yang, H., Liu, N., Li, Y. and Chen, J. (2021) Advances in Pathogenesis of Sjögren’s Syndrome. Journal of Immunology Research, 2021, Article ID: 5928232. [Google Scholar] [CrossRef] [PubMed]
[6] Cafaro, G., Bursi, R., Chatzis, L.G., Fulvio, G., Ferro, F., Bartoloni, E., et al. (2021) One Year in Review 2021: Sjögren’s Syndrome. Clinical and Experimental Rheumatology, 39, 3-13. [Google Scholar] [CrossRef] [PubMed]
[7] Kelly, A.L., Nelson, R.J., Sara, R. and Alberto, S. (2022) Sjögren Syndrome: New Insights in the Pathogenesis and Role of Nuclear Medicine. Journal of Clinical Medicine, 11, Article No. 5227. [Google Scholar] [CrossRef] [PubMed]
[8] Yang, L., Pu, J., Cai, F., Zhang, Y., Gao, R., Zhuang, S., et al. (2023) Chronic Epstein-Barr Virus Infection: A Potential Junction between Primary Sjögren’s Syndrome and Lymphoma. Cytokine, 168, Article ID: 156227. [Google Scholar] [CrossRef] [PubMed]
[9] Maślińska, M. (2019) The Role of Epstein-Barr Virus Infection in Primary Sjögren’s Syndrome. Current Opinion in Rheumatology, 31, 475-483. [Google Scholar] [CrossRef] [PubMed]
[10] 王晶, 李成荫, 王莎莎, 等. EB病毒与干燥综合征发病机制的关系研究进展[J]. 重庆医学, 2021, 50(16): 2835-2838.
[11] Lima, C.M., Santos, S., Dourado, A., Carvalho, N.B., Bittencourt, V., Lessa, M.M., et al. (2016) Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection. Journal of Immunology Research, 2016, Article ID: 8402059. [Google Scholar] [CrossRef] [PubMed]
[12] 周腾. 滋阴润燥方治疗高海拔地区肝肾阴虚型干燥综合征的临床研究[D]: [硕士学位论文]. 西宁: 青海大学, 2022.
[13] 侯佳奇, 薛鸾. 原发性干燥综合征发病机制概述[J]. 现代免疫学, 2019, 39(1): 58-63.
[14] 程增玉, 徐浩东, 庞枫韬, 等. 路志正从阴火论治干燥综合征经验[J]. 中医杂志, 2022, 63(6): 516-520.
[15] 张赛, 张勉之, 侯秀娟, 等. 基于《黄帝内经》“浊阴”理论探讨干燥综合征肾损害的病机与证治[J]. 中华中医药杂志, 2024, 39(6): 2805-2808.
[16] 王宏莉, 赵敏, 胡悦. 胡荫奇论治干燥综合征经验[J]. 时珍国医国药, 2020, 31(11): 2760-2761.
[17] 张潇东, 钟琴, 马武开, 等. 钟琴教授治疗原发性干燥综合征经验拾萃[J]. 中医临床研究, 2024, 16(9): 125-128.
[18] 李娜芬, 陈学勤. 中医治疗干燥综合征的研究进展[J]. 中国民族民间医药, 2022, 31(3): 51-55.
[19] Maleki-Fischbach, M., Kastsianok, L., Koslow, M. and Chan, E.D. (2024) Manifestations and Management of Sjögren’s Disease. Arthritis Research & Therapy, 26, Article No. 43. [Google Scholar] [CrossRef] [PubMed]
[20] Yura, Y. and Hamada, M. (2023) Outline of Salivary Gland Pathogenesis of Sjögren’s Syndrome and Current Therapeutic Approaches. International Journal of Molecular Sciences, 24, Article No. 11179. [Google Scholar] [CrossRef] [PubMed]
[21] Zhang, W., Li, X.M., Xu, D., et al. (2020) Recommendations of Diagnosis and Treatment of Primary Sjogren’s Syndrome in China. Chinese Journal of Internal Medicine, 59, 269-276.
[22] Ramos-Casals, M., Brito-Zerón, P., Bombardieri, S., Bootsma, H., De Vita, S., Dörner, T., et al. (2019) EULAR Recommendations for the Management of Sjögren’s Syndrome with Topical and Systemic Therapies. Annals of the Rheumatic Diseases, 79, 3-18. [Google Scholar] [CrossRef] [PubMed]
[23] 王梦洁, 徐子琦, 刘英. 原发性干燥综合征的中西医治疗新进展[J]. 现代中西医结合杂志, 2021, 30(4): 443-448.
[24] Wang, X., Zhang, T., Guo, Z., Pu, J., Riaz, F., Feng, R., et al. (2021) The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren’s Syndrome: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology, 12, Article ID: 693796. [Google Scholar] [CrossRef] [PubMed]
[25] 凌琰嘉, 苏晓, 陈薇薇, 等. 原发性干燥综合征的发病机制及治疗进展[J]. 医学研究杂志, 2023, 52(7): 7-10.
[26] 梁爽, 姚胜, 高紫欣, 等. 艾拉莫德与羟氯喹治疗原发性干燥综合征有效性和安全性比较的系统分析[J]. 中国免疫学杂志, 2022, 38(5): 591-598.
[27] 周腾, 李琴. 干燥综合征的中西医治疗研究新进展[J]. 中国高原医学与生物学杂志, 2022, 43(2): 142-144.
[28] 杨静, 邓代华. 基础羟氯喹及糖皮质激素联合环磷酰胺冲击治疗原发干燥综合征肺间质病变的疗效与安全性分析[J]. 实用医院临床杂志, 2013, 10(6): 121-123.
[29] Zehrfeld, N., Witte, T. and Ernst, D. (2024) Update Sjögren-Syndrome: Diagnostics, Treatment, and Challenges. Zeitschrift für Rheumatologie, 83, 217-228. [Google Scholar] [CrossRef] [PubMed]
[30] Souza, F.B.d.V., Porfírio, G.J.M., Andriolo, B.N.G., Albuquerque, J.V.d. and Trevisani, V.F.M. (2016) Rituximab Effectiveness and Safety for Treating Primary Sjögren’s Syndrome (pSS): Systematic Review and Meta-Analysis. PLOS ONE, 11, e0150749. [Google Scholar] [CrossRef] [PubMed]
[31] Mariette, X., Barone, F., Baldini, C., Bootsma, H., Clark, K.L., De Vita, S., et al. (2022) A Randomized, Phase II Study of Sequential Belimumab and Rituximab in Primary Sjögren’s Syndrome. JCI Insight, 7, e163030. [Google Scholar] [CrossRef] [PubMed]
[32] Roccatello, D., Saadoun, D., Ramos-Casals, M., Tzioufas, A.G., Fervenza, F.C., Cacoub, P., et al. (2018) Cryoglobulinaemia. Nature Reviews Disease Primers, 4, Article No. 11. [Google Scholar] [CrossRef] [PubMed]
[33] 赵紫嫣, 姜兆荣, 莫成荣. 干燥综合征从肾论治研究进展[J]. 中医临床研究, 2023, 15(15): 27-31.
[34] 朱峰, 孔维萍, 朱笑夏, 等. 阎小萍“辨五液, 调五脏”论治干燥综合征经验[J]. 中华中医药杂志, 2018, 33(10): 4490-4493.
[35] 李雪梅, 贾军峰, 刘璐, 等. 高社光名中医运用“益气养阴、化瘀祛风”治疗原发性干燥综合征经验[J]. 陕西中医, 2021, 42(5): 642-645.
[36] 高雪娇, 汪悦. 干燥综合征从气虚论治[J]. 江苏中医药, 2017, 49(9): 42-44.
[37] 郑新璐, 陈霞, 韦尼. 三焦辨证与分期论治相结合辨治原发性干燥综合征经验[J]. 环球中医药, 2024, 17(5): 891-894.
[38] 赵永璐, 奚然然, 胡袁悦, 等. 干燥综合征从三焦论治的研究进展[J]. 风湿病与关节炎, 2021, 10(10): 70-73.
[39] 吴天勇, 梁昀, 魏璐, 等. 卫气营血辨证治疗燥痹探讨[J]. 山西中医, 2016, 32(7): 1-3.
[40] 何兆春, 李霄鹏, 陈凯, 等. 从卫气营血理论探析燥痹的病机及治疗[J]. 浙江中医药大学学报, 2020, 44(5): 415-418.
[41] 邹蔚萌, 李斌. 六经辨证治疗干燥综合征初探[J]. 环球中医药, 2022, 15(4): 663-666.
[42] 王鹏飞, 姜萍, 刘英. 从气化角度探讨干燥综合征的辨治[J]. 中华中医药杂志, 2019, 34(6): 2532-2534.