维生素D对于女性泌尿生殖道沙眼衣原体感染治疗疗效的探讨

The Therapeutic Efficacy of Vitamin D in the Treatment of Chlamydia trachomatis Infection of the Genitourinary Tract in Women

摘要: 目的：研究维生素D对于女性泌尿生殖道沙眼衣原体感染的应用疗效分析。方法：搜集2023年1月至2024年1月就诊于我院的检测出沙眼衣原体阳性的患者40名，同时选择健康的志愿者40名作为对照组。分别抽取两组患者的血清羟基维生素D(25-(OH)D)的浓度进行对比，其中感染组的患者抽取血清前未进行相关治疗；对感染组患者进行治疗结束后的1个月的血清羟基维生素D(25-(OH)D)的浓度进行检测，对比治愈患者前后血清羟基维生素D(25-(OH)D)的浓度。结果：① CT感染组与健康组的血清25-(OH)D水平进行对比，两组间比较差异有统计学意义(P < 0.05)，而两组间年龄、BMI数值对比，差异无统计学意义(P > 0.05)；② 将治愈患者与未治愈患者的血清25-(OH)D水平进行对比，治愈患者血清25-(OH)D水平为41.37 ± 21.03，未治愈患者血清25-(OH)D水平为29.47 ± 16.66，两组间比较差异有统计学意义(P < 0.05)；③ 病例对照研究显示与维生素D > 50 nmol/L者相比维生素D水平缺乏者的调整OR = 7.188，95%CI: 2.462, 21.147。结论：人泌尿生殖道沙眼衣原体感染及疗效降低与维生素D缺乏相关，血清维生素D水平降低可能会增加泌尿生殖道沙眼衣原体感染风险，并降低疗效。

Abstract: Purpose: Study of the efficacy of vitamin D in the application of Chlamydia trachomatis infection of the genitourinary tract in women. Method: Forty patients who tested positive for Chlamydia trachomatis and 40 healthy volunteers were collected from January 2023 to January 2024, and 40 healthy volunteers were selected as the control group. The serum hydroxyvitamin D (25-(OH)D) concentrations of the two groups of patients were extracted for comparison, in which the patients in the infected group did not undergo any relevant treatment before serum extraction; the serum hydroxyvitamin D(25-(OH)D) one month after the completion of treatment, and ere compared between before and after the cure of the patients. Result: ① The serum 25-(OH)D levels of the CT infected group were compared with those of the healthy group, statistically significant (P < 0.05), whereas the difference between the two groups was not statistically significant when comparing; ② The serum 25-(OH)D levels of the cured patients were compared with those of the untreated patients, the serum 25-(OH)D levels of the cured patients were 41.37 ± 21.03 in cured patients and 29.47 ± 16.66 in non-cured patients, and the difference between the two groups was statistically significant; ③ The case-control study showed that the adjusted OR = 7.188, 95%CI: 2.462, 21.147 in vitamin D deficient patients compared to those with vitamin D > 50 nmol/L. Conclusion: Human genitourinary Chlamydia trachomatis infection and reduced efficacy are associated with vitamin D deficiency, and reduced serum vitamin D levels may increase the risk of genitourinary Chlamydia trachomatis infection and reduce efficacy.