HSIL患者不同手术方式后HPV的转归及影响因素

Regression of HPV in HSIL Patients after Different Surgical Procedures and Factors Affecting It

摘要: 目的：研究HSIL患者进行不同手术方式的处理，随后对患者进行随访，对患者后期HPV的转归结果进行分析。方法：搜集2023年1月至2024年1月就诊于我院的HSIL并接受手术治疗的患者90名，其中按手术方式的不同分为3组，分别是CKC组、LEEP组、锐扶刀组各30名。对于不同手术方式的患者3、6、12个月进行HPV的检测。结果：① 三组患者一般资料对比，年龄、孕次、产次、是否绝经、有无阴道炎、HPV的感染情况对比，差异无统计学意义(P > 0.05)；② 三组患者手术资料的对比，术后切缘状态、是否累腺，三组间比较差异无统计学意义(P > 0.05)，锥切深度的不同在三组间比较差异有统计学意义(P < 0.05)；③ 3、6、12个月时间，三组HPV检测对比，差异无统计学意义(P > 0.05)；④ 将HPV的转阴情况进行多因素分析，可得出是否有阴道炎、是否累及腺体、是否绝经与HPV转阴情况有相关性(P < 0.05)；锥切深度与HPV转阴情况没有相关性(P > 0.05)。结论：HSIL患者不同手术方式均有一定的治疗效果，且术后HPV转阴率与绝经、阴道炎、累腺因素相关。

Abstract: Study of HSIL patients who underwent different surgical modalities and were subsequently followed up to analyze the outcome of late HPV regression in patients. Methods: Ninety patients with HSIL who attended our hospital from January 2023 to January 2024 and underwent surgical treatment were collected, of which 30 patients were divided into three groups according to the different surgical methods, namely, 30 patients each in the CKC group, the LEEP group, and the Sharp Knife group. HPV testing was performed at 3, 6, and 12 months for patients with different surgical procedures. In the end ① Comparison of the general information of the three groups of patients, age, pregnancy, delivery, whether menopause, the presence of vaginitis, HPV infection comparison, the difference is not statistically significant (P > 0.05); ② Comparison of the three groups of patients’ surgical data, postoperative margin status, whether the gland is tired, the difference is not statistically significant among the three groups (P > 0.05), the difference between the three groups of the cone depth of the different comparison of the three groups statistically significant (P < 0.05); ③ 3, 6, 12 months time, the three groups of HPV testing comparison, the difference is not statistically significant (P > 0.05); ④ A multifactorial analysis of the HPV conversion status can be concluded that there is a correlation between whether or not there is vaginitis, whether or not there is gland involvement, and whether or not there is menopause, and the HPV conversion status (P < 0.05); there is no correlation between the depth of conization and the HPV conversion status (P > 0.05). Conclude: The different surgical modalities in HSIL patients were effective, and the postoperative HPV conversion rate was correlated with menopause, vaginitis, and tired gland factors.