原位构筑配体偶联P(V)平台合成α-氨基酸酯类化合物
Synthesis of α-Amino Carboxylic Esters via In-Situ Formed Ligand Coupling P(V) Platform
DOI: 10.12677/jocr.2024.123044, PDF,    科研立项经费支持
作者: 王 楠, 黄媛媛, 訾 由*：南通大学化学化工学院，江苏 南通
关键词: 五配体磷类化合物；配体偶联；α-氨基酸酯；Pentacoordinated Phosphorus Compounds； Ligand Coupling； α-Amino Carboxylic Esters
摘要: 本文主要利用三价膦与邻二羰基化合物的Kukhtin-Ramirez反应中间体原位构筑五配体磷类化合物作为配体偶联的反应平台，一步法实现了α-氨基酸酯类化合物的高效合成。该方法创新性地利用了Kukhtin-Ramirez中间体原位转化为五配体磷类化合物，为需要预合成五配体磷类化合物的传统配体偶联反应模式提供了新的探索方向。
Abstract: In this work, the Kukhtin-Ramirez reaction intermediates from trivalent phosphine and α-dicarbonyl compounds were used to in situ construct pentacoordinated phosphorus compounds as the reaction platform of ligand coupling for the synthesis of α-amino carboxylic esters which was realized in one-step. This approach innovates in the in-situ conversion of Kukhtin-Ramirez inter-mediates into pentacoordinated phosphorus compounds, providing a new direction for the traditional ligand coupling reaction mode that requires pre-synthesis of pentacoordinated phosphorus compounds.
文章引用：王楠, 黄媛媛, 訾由. 原位构筑配体偶联P(V)平台合成α-氨基酸酯类化合物[J]. 有机化学研究, 2024, 12(3): 466-473. https://doi.org/10.12677/jocr.2024.123044

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