重症肺炎患者血清APC，IL-18的表达及其与临床预后的相关性

The Expression of Serum APC and IL-18 in Patients with Severe Pneumonia and Their Correlation with Clinical Prognosis

摘要: 目的：探究重症肺炎患者血清APC，IL-18的表达及其与临床预后的相关性。方法：选取2022年1月~2024年1月我院收治的76例重症肺炎患者作为研究组，选择同期的76名到我院进行体检的健康人员作为对照组，全部研究对象均接受血清APC，IL-18指标的检测。结果：研究组的血清APC水平更低(P < 0.05)，研究组的IL-18水平更高(P < 0.05)；经过回归分析结果表明，血清IL-18、APC水平与重症肺炎患者临床预后情况有关(P < 0.05)；不同预后结果与血清IL-18水平存在明显的正相关性(P < 0.05)，不同预后结果与血清APC水平存在明显的负相关性(P < 0.05)。结论：与健康人员相比较，重症肺炎患者血清APC、IL-18指标出现明显的变化，同时也对重症肺炎患者的预后结果产生明显的影响，为随后临床诊断与治疗工作的开展提供重要的参考依据。

Abstract: Objective: To investigate the expression of serum APC and IL-18 in patients with severe pneumonia and their correlation with clinical prognosis. Method: 76 severe pneumonia patients admitted to our hospital from January 2022 to January 2024 were selected as the study group, and 76 healthy individuals who came to our hospital for physical examination during the same period were selected as the control group. All study subjects underwent serum APC and IL-18 index detection. Result: The serum APC level in the study group was lower (P < 0.05), and the IL-18 level in the study group was higher (P < 0.05); The regression analysis results showed that the levels of serum IL-18 and APC were related to the clinical prognosis of patients with severe pneumonia (P < 0.05); There is a significant positive correlation (P < 0.05) between different prognostic outcomes and serum IL-18 levels, and a significant negative correlation (P < 0.05) between different prognostic outcomes and serum APC levels. Conclusion: Compared with healthy individuals, patients with severe pneumonia show significant changes in serum APC and IL-18 indicators, which also have a significant impact on the prognosis of severe pneumonia patients, providing important reference for subsequent clinical diagnosis and treatment.