间充质干细胞治疗心肌梗死的研究进展：2014年~2023年的文献计量学研究

Research Progress in the Treatment of Myocardial Infarction with Mesenchymal Stem Cells: A Bibliometric Study from 2014 to 2023

摘要: 背景：间充质干细胞是近年医学领域研究的热点，由于其具有易于制备和免疫学特权，为心肌梗死的防治研究提供了新的可能，因此二者之间的可视化分析极其必要。目的：通过可视化分析相关文献，研究间充质干细胞治疗心肌梗死的相关领域，探索了研究现状、热点和发展趋势，为该领域的科研工作者提供参考和借鉴。方法：检索Web of Science数据库中2014年1月1日~2023年12月31日发表的间充质干细胞和心肌梗死的相关文献，使用Excel、VosViewer和Citespace软件对发文量、作者、国家、被引情况和关键词等数据进行统计及可视化分析。结果与结论：共纳入2672篇文献。分析结果显示过去10年关于间充质干细胞治疗心肌梗死研究的发文量呈现逐年上升趋势，在全球范围内，中国和美国是该领域研究的领先国家，同时也是合作交流最多的国家，中国医学科学院北京协和医学院是对研究成果影响最大的研究机构，Hare JM是该领域发文较高产的作者，目前发表的关于间充质干细胞与心肌梗死相关研究的文章大多引用自具有国际影响力的期刊。同种异体和自体间充质干细胞移植能够植入并分化为心肌细胞和血管内皮细胞，减少了心肌梗死后的瘢痕形成，增加了心肌存活率和心脏功能。因此靶向调控间充质干细胞将是未来心肌梗死防治研究的重点。

Abstract: Background: Mesenchymal stem cells have become a hot research topic in the medical field in recent years. Due to their easy preparation and immunological privileges, they provide new possibilities for the prevention and treatment of myocardial infarction. Therefore, visual analysis between the two is extremely necessary. Objective: To visualize and analyze the relevant research literature on mesenchymal stem cell therapy for myocardial infarction, explore the current research status, hotspots, and development trends in this field, and provide reference for researchers in related fields. Method: Retrieve relevant literature on mesenchymal stem cells and myocardial infarction published in the Web of Science database from January 1, 2014 to December 31, 2023. Use Excel, VosViewer, and Citespace software to statistically and visually analyze data such as publication volume, author, country, citation status, and keywords. Results and Conclusion: A total of 2672 articles were included. The analysis results show that the number of publications on mesenchymal stem cell therapy for myocardial infarction has been increasing year by year in the past 10 years. Globally, China and the United States are the leading countries in this field of research, as well as the countries with the most cooperation and exchange. The Peking Union Medical College of the Chinese Academy of Medical Sciences is the research institution with the greatest impact on research results, and Hare JM is a prolific author in this field, Currently, most of the published articles on the relationship between mesenchymal stem cells and myocardial infarction are cited from internationally influential journals. Allogeneic and autologous mesenchymal stem cell transplantation can implant and differentiate into myocardial cells and vascular endothelial cells, reducing scar formation after myocardial infarction, increasing myocardial survival rate and cardiac function. Therefore, targeted regulation of mesenchymal stem cells will be the focus of future research on the prevention and treatment of myocardial infarction.