老龄化影响下脐带间充质干细胞衍生的外泌体促进糖尿病伤口愈合研究进展
Research Progress on the Promotion of Diabetic Wound Healing by Exosomes Derived from Umbilical Cord Mesenchymal Stem Cells under the Influence of Aging
摘要: 随着全球人口老龄化的加剧，老年糖尿病的发病率明显升高，糖尿病患者的伤口愈合问题成为重要的医疗挑战。老年人体内的生理和代谢变化与糖尿病并发症相结合，导致伤口愈合过程延缓和复杂化。糖尿病患者的伤口愈合速度通常比非糖尿病患者慢，特别是在老年人中。脐带间充质干细胞(UCMSCs)衍生的外泌体(Exosomes)因其在细胞再生、免疫调节和血管新生中的潜在作用而被视为一种有前景的治疗策略。本文综述了UCMSCs-exo在糖尿病伤口愈合中的应用进展，探讨了老龄化如何影响这一过程，并展望了未来研究方向。
Abstract: As the global population ages, the incidence of diabetes among the elderly markedly increases, making wound healing in diabetic patients a significant medical challenge. The physiological and metabolic changes in the elderly, coupled with diabetic complications, result in delayed and complicated wound healing processes. Wound healing in diabetic patients is generally slower than in non-diabetic individuals, especially among the elderly. Exosomes derived from Umbilical Cord Mesenchymal Stem Cells (UCMSCs) are seen as a promising therapeutic strategy due to their potential roles in cell regeneration, immune modulation, and angiogenesis. This article reviews the progress of UCMSC-derived exosomes in diabetic wound healing, discusses how aging affects this process, and looks forward to future research directions.
文章引用：颜志勇. 老龄化影响下脐带间充质干细胞衍生的外泌体促进糖尿病伤口愈合研究进展[J]. 老龄化研究, 2024, 11(5): 1823-1830. https://doi.org/10.12677/ar.2024.115264

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