肝脏炎性肌纤维母细胞瘤诊断及治疗相关进展
Advances in the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor of the Liver
DOI: 10.12677/acm.2024.14102782, PDF,   
作者: 周徐雷, 沈宇杰:绍兴文理学院医学院,浙江 绍兴;邵惠江*:绍兴市人民医院肝胆胰外科,浙江 绍兴
关键词: 炎性肌纤维母细胞瘤肝脏临床表现病理组织学诊断治疗Inflammatory Myofibroblastic Tumor Hepatic Clinical Manifestations Histopathology Diagnosis and Treatment
摘要: 炎性肌纤维母细胞瘤(Inflammatory Myofibroblastic Tumor, IMT)最常发生于肺脏,发生在肝脏的比较少见,肝脏炎性肌纤维母细胞瘤是一种非常罕见的具有潜在恶性的肿瘤,完全手术切除后的预后较为良好。然而,它缺乏特定的临床症状和独特的影像学特征。同时,肝脏IMT的罕见性不应降低其在肝脏肿瘤鉴别诊断中的重要性。本文就肝脏炎性肌纤维母细胞瘤(IMT)的临床表现、影像学表现、病理组织学表现、鉴别诊断及诊断治疗策略等方面对其进行全面的阐述以及了解。
Abstract: Inflammatory myofibroblastic tumor (IMT) occurs most often in the lungs, but less commonly in the liver, hepatic inflammatory myofibroblastoma is a very rare potentially malignant tumor, and the prognosis after surgical resection is relatively good. However, it lacks specific clinical symptoms and unique imaging features. At the same time, the rarity of hepatic IMT should not diminish its importance in the differential diagnosis of liver tumors. This article provides a comprehensive introduction and understanding of the clinical manifestations, imaging manifestations, histopathological manifestations, differential diagnosis, and diagnostic and therapeutic strategies of inflammatory myofibroblastoma (IMT) in the liver.
文章引用:周徐雷, 沈宇杰, 邵惠江. 肝脏炎性肌纤维母细胞瘤诊断及治疗相关进展[J]. 临床医学进展, 2024, 14(10): 1171-1176. https://doi.org/10.12677/acm.2024.14102782

参考文献

[1] Brunn, H. (1939) Two Interesting Benign Lung Tumors of Contradictory Histopathology. Journal of Thoracic Surgery, 9, 119-131. [Google Scholar] [CrossRef
[2] 郭祥峰, 高超, 孙华, 等. 我国近20年肝脏炎性肌纤维母细胞瘤流行病学特征及诊治分析[J]. 临床合理用药杂志, 2017, 10(21): 34-36.
[3] Li, M., Sobnach, S., Kotze, U.K., Zerbini, L.F., et al. (2024) Inflammatory Myofibroblastic Tumours of the Liver—A Systematic Review. South African Journal of Surgery, 62, 23-27.
[4] Scali, E.P., Chang, S.D., Abrahams, Z., Tha, S. and Yoshida, E.M. (2014) Inflammatory Pseudotumor of the Liver: A Rare Case of Recurrence Following Surgical Resection. Journal of Radiology Case Reports, 8, 23-30. [Google Scholar] [CrossRef] [PubMed]
[5] Imazu, N., Shibata, M., Koya, Y., Morino, K., Honma, Y., Senju, M., et al. (2020) Hepatic Inflammatory Pseudotumor Protruding from the Liver Surface and Directly Penetrating the Colon. Internal Medicine, 59, 527-532. [Google Scholar] [CrossRef] [PubMed]
[6] Nagarajan, S., Jayabose, S., McBride, W., Prasadh, I., Tanjavur, V., Marvin, M.R., et al. (2013) Inflammatory Myofibroblastic Tumor of the Liver in Children. Journal of Pediatric Gastroenterology and Nutrition, 57, 277-280. [Google Scholar] [CrossRef] [PubMed]
[7] Yang, X., Miao, R., Yang, H., Chi, T., Jiang, C., Wan, X., et al. (2015) Retrospective and Comparative Study of Inflammatory Myofibroblastic Tumor of the Liver. Journal of Gastroenterology and Hepatology, 30, 885-890. [Google Scholar] [CrossRef] [PubMed]
[8] 陈素月, 陈望, 王立环. 肝脏炎性肌纤维母细胞瘤的CT、MRI表现[J]. 临床医学研究与实践, 2023, 8(36): 91-94+112.
[9] Yamamura, K., Beppu, T., Oda, E., Sato, N., Yuki, H., Motohara, T., et al. (2021) Hepatic Inflammatory Pseudotumor Mimicking Malignant Tumor with Rare Onset of Intra-Abdominal Hemorrhage. Anticancer Research, 41, 2727-2732. [Google Scholar] [CrossRef] [PubMed]
[10] 蒋玲君, 徐晓晓, 张道春. 肝脏炎性肌纤维母细胞瘤的CT表现与病理对照[J]. 中国临床医学影像杂志, 2015, 26(7): 487-490.
[11] Liu, X. (2012) Different Imaging Findings of Inflammatory Myofibroblastic Tumor of the Liver. World Journal of Gastroenterology, 18, 5821-5825. [Google Scholar] [CrossRef] [PubMed]
[12] Calistri, L., Maraghelli, D., Nardi, C., Vidali, S., Rastrelli, V., Crocetti, L., et al. (2022) Magnetic Resonance Imaging of Inflammatory Pseudotumor of the Liver: A 2021 Systematic Literature Update and Series Presentation. Abdominal Radiology, 47, 2795-2810. [Google Scholar] [CrossRef] [PubMed]
[13] McDermott, M. (2016) Inflammatory Myofibroblastic Tumour. Seminars in Diagnostic Pathology, 33, 358-366. [Google Scholar] [CrossRef] [PubMed]
[14] 季敏, 李群英, 张大江, 等. 小儿炎性肌纤维母细胞瘤CT/MRI表现分析[J]. 放射学实践, 2017, 32(6): 630-634.
[15] Elpek, G.Ö. (2014) Inflammatory Myofibroblastic Tumor of the Liver: A Diagnostic Challenge. Journal of Clinical and Translational Hepatology, 2, 53-57.
[16] Watanabe, J., Yamada, S., Sasaguri, Y., Guo, X., Kurose, N., Kitada, K., et al. (2019) A Surgical Case of Inflammatory Myofibroblastic Tumor of the Liver: Potentially Characteristic Gross Features. Clinical Medicine Insights: Oncology, 13, Article 1179554919829498. [Google Scholar] [CrossRef] [PubMed]
[17] Coffin, C.M., Watterson, J., Priest, J.R. and Dehner, L.P. (1995) Extrapulmonary Inflammatory Myofibroblastic Tumor (Inflammatory Pseudotumor)—A Clinicopathologic and Immunohistochemical Study of 84 Cases. The American Journal of Surgical Pathology, 19, 859-872. [Google Scholar] [CrossRef] [PubMed]
[18] Solomon, G.J., Kinkhabwala, M.M. and Akhtar, M. (2006) Inflammatory Myofibroblastic Tumor of the Liver. Archives of Pathology & Laboratory Medicine, 130, 1548-1551. [Google Scholar] [CrossRef] [PubMed]
[19] Tang, L., Lai, E.C.H., Cong, W., Li, A., Fu, S., Pan, Z., et al. (2009) Inflammatory Myofibroblastic Tumor of the Liver: A Cohort Study. World Journal of Surgery, 34, 309-313. [Google Scholar] [CrossRef] [PubMed]
[20] 梁泳荣, 黄孙辉, 鲍思扬, 等. 肝脏炎性肌纤维母细胞瘤24例[J]. 世界华人消化杂志, 2014, 22(20): 2952-2956.
[21] Al-Jabri, T., Sanjay, P., Shaikh, I. and Woodward, A. (2010) Inflammatory Myofibroblastic Pseudotumour of the Liver in Association with Gall Stones—A Rare Case Report and Brief Review. Diagnostic Pathology, 5, Article No. 53. [Google Scholar] [CrossRef] [PubMed]
[22] Meng, Y., Xie, J., Liang, Y., Wu, M., Lu, Y. and Lu, Q. (2024) Inflammatory Myofibroblastic Tumor in the Liver: A Case Report. Frontiers in Oncology, 14, Article 1349692. [Google Scholar] [CrossRef] [PubMed]
[23] Devaney, K.O., LaFeir, D.J., Triantafyllou, A., Mendenhall, W.M., Woolgar, J.A., Rinaldo, A., et al. (2012) Inflammatory Myofibroblastic Tumors of the Head and Neck: Evaluation of Clinicopathologic and Prognostic Features. European Archives of Oto-Rhino-Laryngology, 269, 2461-2465. [Google Scholar] [CrossRef] [PubMed]
[24] Antonescu, C.R., Suurmeijer, A.J.H., Zhang, L., Sung, Y., Jungbluth, A.A., Travis, W.D., et al. (2015) Molecular Characterization of Inflammatory Myofibroblastic Tumors with Frequent ALK and ROS1 Gene Fusions and Rare Novel RET Rearrangement. American Journal of Surgical Pathology, 39, 957-967. [Google Scholar] [CrossRef] [PubMed]
[25] Faraj, W., Ajouz, H., Mukherji, D., Kealy, G., Shamseddine, A. and Khalife, M. (2011) Inflammatory Pseudo-Tumor of the Liver: A Rare Pathological Entity. World Journal of Surgical Oncology, 9, Article No. 5. [Google Scholar] [CrossRef] [PubMed]