基于“肝郁血瘀”理论防治血管性痴呆的研究进展

Research Progress in the Prevention and Treatment of Vascular Dementia Based on the Theory of “Liver Depression and Blood Stasis”

摘要: 血管性痴呆(Vascular dementia, VD)作为临床常见的一种严重认知障碍综合征，常表现为记忆、执行等高级认知功能的严重受损。目前，血管性痴呆的患病人群逐年增加，严重影响患者的生存质量，给家庭及社会带来较大的经济和精神负担。常规西医治疗本病以对症、控制脑血管疾病或脑血管危险因素治疗为主，临床效果欠佳。而中医药在临床治疗该病常具有良好的临床疗效，可以延缓该病的进展。本文通过大量分析相关文献、临床观察并结合临床实际疗效，得出“肝郁血瘀”是血管性痴呆的核心病机，故本文以“肝郁血瘀”为角度，从发病机制、临床治疗作出综述，为中医药从“肝郁血瘀”治疗该病提供理论依据。

Abstract: As a common clinical syndrome of severe cognitive impairment, Vascular dementia (VD) is often manifested by severe impairment of higher cognitive functions such as memory and executive function. At present, the number of people with vascular dementia is increasing year by year, which seriously affects the quality of life of patients and brings greater economic and spiritual burden to the family and society. Conventional Western medicine treatment of this disease is mainly to treat the symptoms, control cerebrovascular diseases or cerebrovascular risk factors, and the clinical effect is not good. Traditional Chinese medicine in clinical treatment of the disease often has a good clinical effect and can delay the progression of the disease. Based on a large number of relevant literature analysis, clinical observation and clinical effect, this paper concludes that “liver-stagnation and blood stasis” is the core pathogenesis of vascular dementia. Therefore, this paper reviews the pathogenesis and clinical treatment of “liver-stagnation and blood stasis” from the perspective of “liver-stagnation and blood stasis”, providing a theoretical basis for the treatment of this disease by traditional Chinese medicine.