体检人群同型半胱氨酸与血脂水平相关性分析

Correlation Analysis between Homocysteine and Lipid Levels in a Health Checkup Population

摘要: 目的：探讨体检人群中Hcy水平及其与血脂水平的相关性。方法：分析106,406例体检人群Hcy水平，分别按性别及Hcy水平高低分组，分析Hcy与血脂水平(包括甘油三酯、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇)的关系。结果：总体人群Hcy水平为13.06 μmol/L。男性组Hcy水平为13.98 μmol/L，女性组Hcy水平为11.14 μmol/L，女性组明显低于男性组(P < 0.05)，低Hcy组TC和LDL-C水平明显低于高Hcy组(P < 0.05)，而低Hcy组HDL-C水平明显高于高Hcy组(P < 0.05)。结论：Hcy水平存在性别差异，健康体检人群Hcy水平与血脂中的LDL-C和TC具有正相关性，与HDL-C具有负相关性。应加强对重点人群Hcy水平的监控，有助于更深入地了解Hcy和血脂的关系，为临床上血脂代谢异常的预防和治疗提供参考。

Abstract: Objective: To investigate the levels of Homocysteine (Hcy) and their correlation with lipid levels in a population undergoing health checkups. Methods: The study analyzed the Hcy levels of 106,406 individuals and categorized them by gender and Hcy levels. The relationship between Hcy and lipids levels (including triglycerides, total cholesterol, Low-Density Lipoprotein Cholesterol (LDL-C), and High-Density Lipoprotein Cholesterol (HDL-C)) was assessed. Results: The average Hcy level in the overall population was 13.06 μmol/L. The Hcy level for males was 13.98 μmol/L, while for females, it was 11.14 μmol/L, which was significantly lower than that of males (P < 0.05). The low Hcy group had significantly lower levels of Total Cholesterol (TC) and LDL-C compared to the high Hcy group (P < 0.05), while the HDL-C level in the low Hcy group was significantly higher than in the high Hcy group (P < 0.05). Conclusion: There is a gender difference in Hcy levels. In the health checkup population, Hcy levels are positively correlated with LDL-C and TC, and negatively correlated with HDL-C. Monitoring Hcy levels in key populations should be strengthened to better understand the relationship between Hcy and lipid levels, which can provide references for the prevention and treatment of lipid metabolism disorders in clinical practice.