恒古骨伤愈合剂治疗骨疾病的研究进展
Research Progress of Osteoking on Bone Diseases
DOI: 10.12677/acm.2024.14112915, PDF,    科研立项经费支持
作者: 马 童, 缪 敏：昆明医科大学药学院暨云南省天然药物药理重点实验室，云南 昆明；昆明医科大学云南省现代生物医药产业学院，云南 昆明；吴 迪：昆明医科大学第一附属医院创伤中心，云南 昆明；朱 迪*：云南省第三人民医院急诊内科，云南 昆明
关键词: 恒古骨伤愈合剂；骨质疏松；股骨头坏死；膝骨关节炎；腰椎间盘突出症；Osteoking； Osteoporosis (OP)； Osteonecrosis of the Femoral Head； Knee Osteoarthritis (KOA)； Lumbar Disc Herniation (LDH)
摘要: 恒古骨伤愈合剂(Osteoking)是一种云南彝族传统复方民族药物，临床研究表明Osteoking在骨疾病治疗方面有积极效果。本文讨论了现有Osteoking治疗骨疾病的药理机制，包括骨质疏松、股骨头坏死、膝骨关节炎和腰椎间盘突出症等骨疾病。通过查阅Osteoking治疗骨疾病的中、英文文献，论述Osteoking治疗以上骨疾病的临床研究进展，旨在为临床应用Osteoking治疗骨疾病提供理论参考。
Abstract: Osteoking is a kind of traditional compound medicine of Yi nationality in Yunnan province. Clinical research shows that Osteoking has positive effect in the treatment of bone diseases. The pharmacological mechanism of Osteoking in the treatment of bone diseases, including osteoporosis, osteonecrosis of the femoral head, osteoarthritis of the knee and protrusion of the lumbar intervertebral disc, was discussed. By reviewing the Chinese and English literatures of Osteoking in the treatment of bone diseases, this paper discusses the clinical research progress of Osteoking in the treatment of the above bone diseases in order to provide theoretical reference for the clinical application of Osteoking in the treatment of bone diseases.
文章引用：马童, 缪敏, 吴迪, 朱迪. 恒古骨伤愈合剂治疗骨疾病的研究进展[J]. 临床医学进展, 2024, 14(11): 561-567. https://doi.org/10.12677/acm.2024.14112915

参考文献

[1] 贺美宇, 李兆勇, 张晨阳, 等. 探讨彝药恒古骨伤愈合剂治疗骨质疏松症的系统药理学作用机制[J]. 中国骨质疏松杂志, 2021, 27(12): 1827-1832.
[2] 胡敏, 王兵, 赵宏斌, 等. 恒古骨伤愈合剂预防性给药对股骨颈骨折术后半年股骨头坏死发生率及负重髋疼痛程度的影响[J]. 中国临床康复, 2005, 9(14): 158-159.
[3] 赵宏斌, 胡敏, 邱智兴, 等. 恒古骨伤愈合剂治疗腰椎间盘突出症37例长期疗效观察[J]. 云南中医中药杂志, 2006, 27(5): 3-4.
[4] 周兆文, 普有登, 袁晓峰, 等. 恒古骨伤愈合剂治疗急性腰扭伤的疗效观察[J]. 云南医药, 2012, 33(5): 435-436.
[5] Finkelstein, J.S., Hayes, A., Hunzelman, J.L., Wyland, J.J., Lee, H. and Neer, R.M. (2003) The Effects of Parathyroid Hormone, Alendronate, or Both in Men with Osteoporosis. New England Journal of Medicine, 349, 1216-1226. [Google Scholar] [CrossRef] [PubMed]
[6] Drake, M.T., Clarke, B.L. and Lewiecki, E.M. (2015) The Pathophysiology and Treatment of Osteoporosis. Clinical Therapeutics, 37, 1837-1850. [Google Scholar] [CrossRef] [PubMed]
[7] 中华医学会骨质疏松和骨矿盐疾病分会. 原发性骨质疏松症诊治指南[J]. 中华骨质疏松和骨矿盐疾病杂志, 2011, 4(1): 2-17.
[8] Okagu, I.U., Ezeorba, T.P.C., Aguchem, R.N., Ohanenye, I.C., Aham, E.C., Okafor, S.N., et al. (2022) A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases. International Journal of Molecular Sciences, 23, Article No. 8468. [Google Scholar] [CrossRef] [PubMed]
[9] Grey, A. and Reid, I.R. (2005) Emerging and Potential Therapies for Osteoporosis. Expert Opinion on Investigational Drugs, 14, 265-278. [Google Scholar] [CrossRef] [PubMed]
[10] Lane, N.E. and Kelman, A. (2003) A Review of Anabolic Therapies for Osteoporosis. Arthritis Research & Therapy, 5, 214-222. [Google Scholar] [CrossRef] [PubMed]
[11] 王素彬, 赵宏斌, 胡敏, 等. 恒古骨伤愈合剂对骨质疏松性骨折兔骨密度及DKK-1蛋白的影响[J]. 中国中西医结合杂志, 2015, 35(8): 1000-1003.
[12] Roberts, A.B., Anzano, M.A., Lamb, L.C., Smith, J.M. and Sporn, M.B. (1981) New Class of Transforming Growth Factors Potentiated by Epidermal Growth Factor: Isolation from Non-Neoplastic Tissues. Proceedings of the National Academy of Sciences, 78, 5339-5343. [Google Scholar] [CrossRef] [PubMed]
[13] Fennen, M., Pap, T. and Dankbar, B. (2016) Smad-Dependent Mechanisms of Inflammatory Bone Destruction. Arthritis Research & Therapy, 18, Article No. 279. [Google Scholar] [CrossRef] [PubMed]
[14] Hara, Y., Ghazizadeh, M., Shimizu, H., Matsumoto, H., Saito, N., Yagi, T., et al. (2017) Delayed Expression of Circulating TGF-β1 and BMP-2 Levels in Human Nonunion Long Bone Fracture Healing. Journal of Nippon Medical School, 84, 12-18. [Google Scholar] [CrossRef] [PubMed]
[15] 郑红, 进涛, 袁鑫, 等. 恒古骨伤愈合剂通过TGF-β/Smad信号通路促进去势骨质疏松症大鼠BMSCs增殖[J]. 昆明医科大学学报, 2018, 39(3): 5-10.
[16] 角建林, 唐薇, 郑红, 等. 彝药恒古骨伤愈合剂缓解去势树鼩骨质疏松症[J]. 基础医学与临床, 2018, 38(12): 1686-1690.
[17] 郑红, 李进涛, 赵宏斌, 等. 恒古骨伤愈合剂对骨质疏松症树鼩Wnt/β-catenin信号通路激活作用的实验研究[J]. 中国中医药科技, 2018, 25(5): 644-648.
[18] 郑红, 赵宏斌, 袁鑫. 恒古骨伤愈合剂通过PI3K/AKT/GSK-3β信号通路治疗树鼩绝经后骨质疏松的作用机制[J]. 中国老年学杂志, 2019, 39(3): 626-630.
[19] 崔朋涛. 骨蚀再造丸治疗肾虚血瘀证股骨头坏死的临床研究[D]: [硕士毕业论文]. 郑州: 河南中医药大学, 2021.
[20] Long, H., Sun, B., Cheng, L., Zhao, S., Zhu, Y., Zhao, R., et al. (2017) miR-139-5p Represses BMSC Osteogenesis via Targeting Wnt/β-Catenin Signaling Pathway. DNA and Cell Biology, 36, 715-724. [Google Scholar] [CrossRef] [PubMed]
[21] Guo, Q., Chen, Y., Guo, L., Jiang, T. and Lin, Z. (2016) miR-23a/b Regulates the Balance between Osteoblast and Adipocyte Differentiation in Bone Marrow Mesenchymal Stem Cells. Bone Research, 4, Article No. 16022. [Google Scholar] [CrossRef] [PubMed]
[22] Kang, P.D., et al. (2008) Lovastatin Inhibits Adipogenesis and Prevents Osteonecrosis in Steroid-Treated Rabbits. Joint Bone Spine, 75, 696-701. [Google Scholar] [CrossRef] [PubMed]
[23] 高梅. 他汀类药物治疗激素性股骨头坏死的效果及机制研究[J]. 中国医药指南, 2018, 16(28): 144-145.
[24] 沈相霖. 股骨头坏死的治疗进展[J]. 大医生, 2017, 2(9): 122-123.
[25] 赵宏斌, 梁红琐, 胡敏, 等. 恒古骨伤愈合剂促进坏死股骨头内BMP-2基因表达研究[J]. 中药药理与临床, 2006, 22(6): 61-63.
[26] 赵宏斌, 胡敏, 梁红锁, 等. 恒古骨伤愈合剂促进兔坏死股骨头内核心结合因子α1基因表达的实验研究[J]. 中国中西医结合杂志, 2006, 26(11): 1003-1006.
[27] 赵宏斌, 胡敏, 王维琦, 等. 恒古骨伤愈合剂对激素性坏死股骨头内VEGF基因表达的影响[J]. 中国骨伤, 2007, 20(11): 757-759.
[28] 胡敏, 赵宏斌, 董锡亮, 等. 恒古骨伤愈合剂对激素性股骨头坏死兔模型干预的组织外观和光镜观察[J]. 中国中药杂志, 2010, 35(21): 2912-2916.
[29] 于海峰, 黄青, 张宁. 恒古骨伤愈合剂治疗Ⅱ期股骨头缺血性坏死60例临床观察[C]//跨世纪骨伤杰出人才科技成果荟萃. 辽源: 中国人才研究会骨伤人才分会, 2004: 941-942.
[30] 吕汐妍, 任超展, 寄婧, 等. 等速离心训练联合股内侧肌电刺激治疗膝关节骨性关节炎临床疗效研究[J]. 中国康复医学杂志, 2021, 36(11): 1433-1435.
[31] Zhao, X., Meng, F., Hu, S., Yang, Z., Huang, H., Pang, R., et al. (2020) The Synovium Attenuates Cartilage Degeneration in KOA through Activation of the Smad2/3-Runx1 Cascade and Chondrogenesis-Related miRNAs. Molecular Therapy—Nucleic Acids, 22, 832-845. [Google Scholar] [CrossRef] [PubMed]
[32] Guo, Y., Xu, Y., He, M., Chen, X., Xing, L., Hu, T., et al. (2023) Acupotomy Improves Synovial Hypoxia, Synovitis and Angiogenesis in KOA Rabbits. Journal of Pain Research, 16, 749-760. [Google Scholar] [CrossRef] [PubMed]
[33] Wang, T., Li, L., Tan, C., Yang, J., Shi, G., Wang, L., et al. (2021) Effect of Electroacupuncture on Gut Microbiota in Participants with Knee Osteoarthritis. Frontiers in Cellular and Infection Microbiology, 11, Article ID: 597431. [Google Scholar] [CrossRef] [PubMed]
[34] Tang, X., Wang, S., Zhan, S., Niu, J., Tao, K., Zhang, Y., et al. (2016) The Prevalence of Symptomatic Knee Osteoarthritis in China: Results from the China Health and Retirement Longitudinal Study. Arthritis & Rheumatology, 68, 648-653. [Google Scholar] [CrossRef] [PubMed]
[35] Zhang, J., Song, L., Wei, J., Zhang, A., Dong, H., Wen, H., et al. (2014) Prevalence of and Risk Factors for the Occurrence of Symptomatic Osteoarthritis in Rural Regions of Shanxi Province, China. International Journal of Rheumatic Diseases, 19, 781-789. [Google Scholar] [CrossRef] [PubMed]
[36] Bannuru, R.R., Osani, M.C., Vaysbrot, E.E., Arden, N.K., Bennell, K., Bierma-Zeinstra, S.M.A., et al. (2019) OARSI Guidelines for the Non-Surgical Management of Knee, Hip, and Polyarticular Osteoarthritis. Osteoarthritis and Cartilage, 27, 1578-1589. [Google Scholar] [CrossRef] [PubMed]
[37] Bally, M., Dendukuri, N., Rich, B., Nadeau, L., Helin-Salmivaara, A., Garbe, E., et al. (2017) Risk of Acute Myocardial Infarction with NSAIDs in Real World Use: Bayesian Meta-Analysis of Individual Patient Data. BMJ, 357, j1909. [Google Scholar] [CrossRef] [PubMed]
[38] 徐涛涛, 郑凌歆, 孙岩, 等. 恒古骨伤愈合剂治疗膝骨性关节炎的临床疗效及安全性评价[J]. 中国中医骨伤科杂志, 2022, 30(2): 8-12.
[39] 谭学松, 匡浩铭, 熊杰, 等. 恒古骨伤愈合剂治疗肝肾亏虚型膝骨关节30例[J]. 中国中医骨伤科杂志, 2021, 29(8): 44-47.
[40] 谢斌, 何海军, 闫波, 等. 古骨伤愈合剂联合特定电磁波治疗气滞血瘀型膝骨关节炎的多维度疗效分析[J]. 中国实验方剂学杂志, 2022, 28(13): 130-136.
[41] Benzakour, T., Igoumenou, V., Mavrogenis, A.F. and Benzakour, A. (2018) Current Concepts for Lumbar Disc Herniation. International Orthopaedics, 43, 841-851. [Google Scholar] [CrossRef] [PubMed]
[42] 王邦博, 杨晓倩, 栾逸先. 针灸治疗腰椎间盘突出症的临床研究进展[J]. 广州中医药大学报, 2022, 39(9): 2206-2212.
[43] 汪武贵, 周勇, 李伟, 等. 恒古骨伤愈合剂联合接骨七厘片对桡骨远端骨折愈合效果的影响[J]. 现代生物医学进展, 2016, 16(33): 6474-6476.
[44] 叶子丰, 匡浩铭, 沈琳玲, 等. 恒古骨伤愈合剂口服联合透药治疗腰椎间盘突出症临床研究[J]. 新中医, 2022, 54(13): 83-87.
[45] 匡建军, 张信成, 罗星华, 等. 肿痛消巴布膏对炎性渗出液中PGE2, IL-6含量的影响[J]. 中国实验方剂学杂志, 2012, 18(5): 236-237.
[46] 黄振星, 杨少锋, 郭彦涛, 等. 恒古骨伤愈合剂治疗瘀血阻络型腰椎间盘突出症的临床疗效[J]. 中国中医骨伤科杂志, 2022, 30(3): 35-38.
[47] 袁鑫, 武羽洁, 角建林, 等. 彝药恒古骨伤愈合剂的药理作用和临床应用[J]. 中国现代应用药学, 2019, 36(3): 372-376.
[48] 杨琳, 林万程, 施家乐, 等. 三七总皂苷药理作用的研究进展[J]. 安徽医药, 2014, 18(5): 963-965.
[49] 刘宁, 刘媛, 潘蕾, 等. 红花的研究进展[J]. 中国医药导刊, 2017, 19(5): 527-530.

为你推荐