血脂变异性与心血管疾病关联的研究进展
Research Progress on the Association between Lipid Variability and Cardiovascular Diseases
DOI: 10.12677/acm.2024.14112936, PDF,    国家自然科学基金支持
作者: 何 杰, 焦 岚, 刘地川*：重庆医科大学附属第二医院心血管内科，重庆
关键词: 血脂变异性；心血管疾病；研究进展；Lipid Variability； Cardiovascular Disease； Research Progress
摘要: 心血管疾病(Cardiovascular Disease, CVD)是威胁全球居民健康的主要负担之一。近年来，血脂水平的变异性被认为是心血管疾病风险的一个重要因素。因此，本文综述了近年来关于血脂变异性与心血管疾病之间关系的研究进展，为今后临床实践中的血脂管理提供进一步的参考。
Abstract: Cardiovascular disease (CVD) stands as one of the principal burdens to the health of the global population. In recent years, lipid variability has emerged as a significant factor in the risk of CVD. Consequently, this paper provides an overview of the advancements in research concerning the relationship between lipid variability and cardiovascular diseases, aiming to offer additional guidance for lipid management in future clinical practices.
文章引用：何杰, 焦岚, 刘地川. 血脂变异性与心血管疾病关联的研究进展[J]. 临床医学进展, 2024, 14(11): 715-720. https://doi.org/10.12677/acm.2024.14112936

参考文献

[1] 国家心血管病中心, 中国心血管健康与疾病报告编写组, 胡盛寿. 中国心血管健康与疾病报告2023概要[J]. 中国循环杂志, 2024, 39(7): 625-660.
[2] Wang, H., Zhang, H. and Zou, Z. (2023) Changing Profiles of Cardiovascular Disease and Risk Factors in China: A Secondary Analysis for the Global Burden of Disease Study 2019. Chinese Medical Journal, 136, 2431-2441. [Google Scholar] [CrossRef] [PubMed]
[3] Yusuf, S., Reddy, S., Ôunpuu, S. and Anand, S. (2001) Global Burden of Cardiovascular Diseases: Part I: General Considerations, the Epidemiologic Transition, Risk Factors, and Impact of Urbanization. Circulation, 104, 2746-2753. [Google Scholar] [CrossRef] [PubMed]
[4] Simpson, W.G. (2019) Biomarker Variability and Cardiovascular Disease Residual Risk. Current Opinion in Cardiology, 34, 413-417. [Google Scholar] [CrossRef] [PubMed]
[5] Stevens, S.L., Wood, S., Koshiaris, C., Law, K., Glasziou, P., Stevens, R.J., et al. (2016) Blood Pressure Variability and Cardiovascular Disease: Systematic Review and Meta-Analysis. BMJ, 354, i4098. [Google Scholar] [CrossRef] [PubMed]
[6] Hillebrand, S., Gast, K.B., de Mutsert, R., Swenne, C.A., Jukema, J.W., Middeldorp, S., et al. (2013) Heart Rate Variability and First Cardiovascular Event in Populations without Known Cardiovascular Disease: Meta-Analysis and Dose-Response Meta-Regression. EP Europace, 15, 742-749. [Google Scholar] [CrossRef] [PubMed]
[7] Gorst, C., Kwok, C.S., Aslam, S., Buchan, I., Kontopantelis, E., Myint, P.K., et al. (2015) Long-Term Glycemic Variability and Risk of Adverse Outcomes: A Systematic Review and Meta-Analysis. Diabetes Care, 38, 2354-2369. [Google Scholar] [CrossRef] [PubMed]
[8] Bangalore, S., Fayyad, R., Laskey, R., DeMicco, D.A., Messerli, F.H. and Waters, D.D. (2017) Body-Weight Fluctuations and Outcomes in Coronary Disease. New England Journal of Medicine, 376, 1332-1340. [Google Scholar] [CrossRef] [PubMed]
[9] Croover, M.E., Jernican, J.A. and Martin, C.D. (1960) Variations in Serum Lipid Concentration and Clinical Coronary Disease. The American Journal of the Medical Sciences, 239, 133-139. [Google Scholar] [CrossRef] [PubMed]
[10] Kreger, B.E., Odell, P.M., D'Agostino, R.B. and Wilson, P.F.W. (1994) Long-Term Intraindividual Cholesterol Variability: Natural Course and Adverse Impact on Morbidity and Mortality—The Framingham Study. American Heart Journal, 127, 1607-1614. [Google Scholar] [CrossRef] [PubMed]
[11] Bautista, L.E. and Rueda-Ochoa, O.L. (2021) Methodological Challenges in Studies of the Role of Blood Lipids Variability in the Incidence of Cardiovascular Disease. Lipids in Health and Disease, 20, Article No. 51. [Google Scholar] [CrossRef] [PubMed]
[12] Bangalore, S., Breazna, A., DeMicco, D.A., Wun, C. and Messerli, F.H. (2015) Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability and Risk of Cardiovascular Outcomes. Journal of the American College of Cardiology, 65, 1539-1548. [Google Scholar] [CrossRef] [PubMed]
[13] Lee, E.Y., Yang, Y., Kim, H., Cho, J., Yoon, K., Chung, W.S., et al. (2018) Effect of Visit-to-Visit LDL-, HDL-, and Non-HDL-Cholesterol Variability on Mortality and Cardiovascular Outcomes after Percutaneous Coronary Intervention. Atherosclerosis, 279, 1-9. [Google Scholar] [CrossRef] [PubMed]
[14] Clark, D., Nicholls, S.J., St. John, J., Elshazly, M.B., Kapadia, S.R., Tuzcu, E.M., et al. (2018) Visit-to-Visit Cholesterol Variability Correlates with Coronary Atheroma Progression and Clinical Outcomes. European Heart Journal, 39, 2551-2558. [Google Scholar] [CrossRef] [PubMed]
[15] Waters, D.D., Bangalore, S., Fayyad, R., DeMicco, D.A., Laskey, R., Melamed, S., et al. (2018) Visit-to-Visit Variability of Lipid Measurements as Predictors of Cardiovascular Events. Journal of Clinical Lipidology, 12, 356-366. [Google Scholar] [CrossRef] [PubMed]
[16] Boey, E., Gay, G.M.W., Poh, K., Yeo, T., Tan, H. and Lee, C. (2016) Visit-to-Visit Variability in LDL-and HDL-Cholesterol Is Associated with Adverse Events after ST-Segment Elevation Myocardial Infarction: A 5-Year Follow-Up Study. Atherosclerosis, 244, 86-92. [Google Scholar] [CrossRef] [PubMed]
[17] Liu, X., Wu, S., Song, Q. and Wang, X. (2020) Visit-to-Visit Variability of Lipid Measurements and the Risk of Myocardial Infarction and All-Cause Mortality: A Prospective Cohort Study. Atherosclerosis, 312, 110-116. [Google Scholar] [CrossRef] [PubMed]
[18] Kim, M.K., Han, K., Kim, H., Park, Y., Kwon, H., Yoon, K., et al. (2017) Cholesterol Variability and the Risk of Mortality, Myocardial Infarction, and Stroke: A Nationwide Population-Based Study. European Heart Journal, 38, 3560-3566. [Google Scholar] [CrossRef] [PubMed]
[19] Wu, Y., Shen, P., Xu, L., Yang, Z., Sun, Y., Yu, L., et al. (2023) Association between Visit-to-Visit Lipid Variability and Risk of Ischemic Heart Disease: A Cohort Study in China. Endocrine, 84, 914-923. [Google Scholar] [CrossRef] [PubMed]
[20] Koh, S.M., Chung, S.H., Yum, Y.J., Park, S.J., Joo, H.J., Kim, Y., et al. (2022) Comparison of the Effects of Triglyceride Variability and Exposure Estimate on Clinical Prognosis in Diabetic Patients. Cardiovascular Diabetology, 21, Article No. 245. [Google Scholar] [CrossRef] [PubMed]
[21] Lim, S., Chung, S.H., Kim, J.H., Kim, Y.H., Kim, E.J. and Joo, H.J. (2023) Effects of Metabolic Parameters’ Variability on Cardiovascular Outcomes in Diabetic Patients. Cardiovascular Diabetology, 22, Article No. 114. [Google Scholar] [CrossRef] [PubMed]
[22] Wang, M., Li, C., Liu, C., Lin, C., Yang, S., Li, T., et al. (2021) Effect of Blood Lipid Variability on Mortality in Patients with Type 2 Diabetes: A Large Single-Center Cohort Study. Cardiovascular Diabetology, 20, Article No. 228. [Google Scholar] [CrossRef] [PubMed]
[23] Abela, G.S., Vedre, A., Janoudi, A., Huang, R., Durga, S. and Tamhane, U. (2011) Effect of Statins on Cholesterol Crystallization and Atherosclerotic Plaque Stabilization. The American Journal of Cardiology, 107, 1710-1717. [Google Scholar] [CrossRef] [PubMed]
[24] Abela, G.S., Aziz, K., Vedre, A., Pathak, D.R., Talbott, J.D. and DeJong, J. (2009) Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients with Acute Coronary and Cerebrovascular Syndromes. The American Journal of Cardiology, 103, 959-968. [Google Scholar] [CrossRef] [PubMed]
[25] Nakano, S., Otake, H., Kawamori, H., Toba, T., Sugizaki, Y., Nagasawa, A., et al. (2021) Association between Visit-to-Visit Variability in Low-Density Lipoprotein Cholesterol and Plaque Rupture That Leads to Acute Coronary Syndrome. Circulation Reports, 3, 540-549. [Google Scholar] [CrossRef] [PubMed]
[26] Rohatgi, A., Khera, A., Berry, J.D., Givens, E.G., Ayers, C.R., Wedin, K.E., et al. (2014) HDL Cholesterol Efflux Capacity and Incident Cardiovascular Events. New England Journal of Medicine, 371, 2383-2393. [Google Scholar] [CrossRef] [PubMed]
[27] Tall, A.R. and Yvan-Charvet, L. (2015) Cholesterol, Inflammation and Innate Immunity. Nature Reviews Immunology, 15, 104-116. [Google Scholar] [CrossRef] [PubMed]
[28] Chen, H., Ren, J., Xing, Y., Zhang, W., Liu, X., Wu, P., et al. (2009) Short-Term Withdrawal of Simvastatin Induces Endothelial Dysfunction in Patients with Coronary Artery Disease: A Dose-Response Effect Dependent on Endothelial Nitric Oxide Synthase. International Journal of Cardiology, 131, 313-320. [Google Scholar] [CrossRef] [PubMed]
[29] Davignon, J. (2004) Beneficial Cardiovascular Pleiotropic Effects of Statins. Circulation, 109, 39-43. [Google Scholar] [CrossRef] [PubMed]
[30] Heeschen, C., Hamm, C.W., Laufs, U., Snapinn, S., Böhm, M. and White, H.D. (2002) Withdrawal of Statins Increases Event Rates in Patients with Acute Coronary Syndromes. Circulation, 105, 1446-1452. [Google Scholar] [CrossRef] [PubMed]
[31] Daskalopoulou, S.S., Delaney, J.A.C., Filion, K.B., Brophy, J.M., Mayo, N.E. and Suissa, S. (2008) Discontinuation of Statin Therapy Following an Acute Myocardial Infarction: A Population-Based Study. European Heart Journal, 29, 2083-2091. [Google Scholar] [CrossRef] [PubMed]
[32] Lissner, L., Odell, P.M., D’Agostino, R.B., Stokes, J., Kreger, B.E., Belanger, A.J., et al. (1991) Variability of Body Weight and Health Outcomes in the Framingham Population. New England Journal of Medicine, 324, 1839-1844. [Google Scholar] [CrossRef] [PubMed]

为你推荐