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Gertler, M.M., Garn, S.M. and Levine, S.A. (2012) Serum uric acid in relation to age and physique in health and in coronary heart disease. Annals of Internal Medicine, 34, 1421-1431.


  • 标题: MPV、FIB、UA水平与冠心病的关系及研究进展Progress and Relationship between Level of MPV, FIB, UA and Coronary Heart Disease

    作者: 贾梅, 刘志跃, 杜秀丽

    关键字: 冠心病, 血小板平均体积, 纤维蛋白原, 尿酸, 预测Coronary Heart Disease, Mean Platelet Volume, Fibrinogen, Uric Acid, Prediction

    期刊名称: 《Advances in Clinical Medicine》, Vol.5 No.2, 2015-06-19

    摘要: 冠心病严重威胁人类健康,它是多种因素导致的疾病,除了以往的主要危险因素外,近年来大量研究发现,血小板平均体积、血浆纤维蛋白原、血尿酸与冠心病的发生、发展及预后密切相关。MPV是血小板活化的生物学指标,FIB是重要的凝血因子,血尿酸则是重要的炎性因子,通过不同的机制促进血栓形成,参与动脉粥样硬化的发生、发展。联合检测以上三项指标,有可能提高其对冠心病的早期诊断及冠脉病变严重程度的预测价值。本文就血小板平均体积、血浆纤维蛋白原、血尿酸与冠心病的关系及研究进展做一综述。 Coronary heart disease is a serious threat to human health, it is a disease caused by a variety of factors, in addition to main risk factors, in recent years, a large number of studies have found that mean platelet volume, fibrinogen and uric acid is closely related to the occurrence, development and prognosis of coronary heart disease. Mean platelet volume is a biological indicator of platelet activation, fibrinogen is an important clotting factor, uric acid is an important inflammatory cyto-kines, through different mechanisms result in thrombosis, and participate in the occurrence and development of atherosclerosis. Combined detection of three indicators, it is possible to improve its predictive value of early diagnosis and the severity of coronary lesions in coronary heart disease. This paper reviews the progress and relationship between level of mean platelet volume, fibrinogen, uric acid and coronary heart disease.