标题:
复方樟柳碱穴位注射治疗干眼症的循证研究Evidence-Based Research of Acupoint Injection of Compound Anisodine to Treat Dry Eye Syndrome
作者:
夏朝霞, 杨筱曦, 冯志贞, 陈向华, 马演玲, 屈蕾, 陈斐妮
关键字:
复方樟柳碱, 颞浅动脉, 干眼Compound Anisodine, Arteria Temporalis Superficialis, Dry Eye
期刊名称:
《Hans Journal of Ophthalmology》, Vol.5 No.3, 2016-09-13
摘要:
目的：应用复方樟柳碱(compound anisodine, CA)注射液行颞浅动脉旁注射治疗干眼症，探讨干眼恢复的效果。方法：采用复方樟柳碱注射液2 ml对单纯性干眼症患者50例和难治性干眼症患者82例，行颞浅动脉旁注射2~5个疗程，观察注射前后干眼的各项指标：泪膜破裂时间(break-up time, BUT)、基础泪液分泌试验(Schinmer II test, Sit II)、角膜荧光素钠染色(fluorescein, FL)及干涩、刺痛、流泪、畏光、异物感、视物模糊等症状。结果：治疗2~5个疗程后分别观察上述指标，干涩、异物感减轻，刺痛、流泪、畏光、视物模糊消失，与治疗前比较BUT明显延长(t = 25.366, 22.125, 17.148)，SIt分泌增加(t = −14.726, −17.213, −7.256)，FL染色率也明显减少。差异均有统计学意义(p
Objective: To evaluate the improvement of xerophthalmia following acupoint injection compound anisodine (CA) in the patients with scheroma. Methods: This randomized study involved 50 cases (50 eyes) with simple patients with scheroma and 82 cases (82 eyes) with refractory patients with scheroma. All patients with scheroma were treated for 2 - 5 courses of treatment by acupoint in-jection compound anisodine 2 milliliter (ml) in lateral arteria temporalis superficialis. The symp-toms of dry eye, tear break-up time (BUT), Schinmer II test (SIt) value and corneal fluorescein staining (FL), including dry feeling, stinging sensation, lachrymation, photophobia, fricative feeling, indistinct vision were measured pre-therapy and post-treatment. Results: At post-treatment for 2 - 5 courses, all symptoms of aforementioned disappeared. The subjective complains of dry eye improved. The mean SIt (t = −14.726, −17.213, −7.256) and BUT (t = 25.366, 22.125, 17.148) lengthened significantly (p