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Brennan, F.H., Anderson, A.J., Taylor, S.M., Woodruff, T.M. and Ruitenberg, M.J. (2012) Complement activation in the injured central nervous system: Another dual-edged sword? Journal of Neuroinflammation, 9, 137.


  • 标题: 免疫机制在脑继发性损伤过程中的作用The Role of Immune Mechanism in the Process of Secondary Brain Injury

    作者: 黄德智, 杨金福

    关键字: 免疫机制, 继发性脑损伤, 脑缺血Immune Mechanism, Secondary Brain Injury, Cerebral Ischemia

    期刊名称: 《Advances in Clinical Medicine》, Vol.4 No.2, 2014-06-18

    摘要: 目前许多研究表明,免疫反应在大脑缺血后的损伤中扮演着重要的角色。淋巴细胞及固有免疫都不同程度的参与继发性脑细胞损伤的过程,这些免疫细胞被激活后均通过释放相关免疫因子而引起不同程度的大脑缺血损伤及缺血再灌注损伤。而找到这些免疫细胞的相关产物,并干预其在大脑缺血后的表达,则可不同程度减小大脑缺血及缺血再灌注损伤。有关免疫系统对大脑损伤的研究在不断进步,本文将介绍有关免疫系统对大脑损伤近年来的研究进展。 Many studies have shown that the immune response plays an important role in post-ischemic brain injury. Lymphocytes and innate immunity participate in the process of post-ischemic brain injury, and these immune cells are activated through the release of immune factors, which are involved in ischemic injury and ischemia-reperfusion injury. If we find relevant products of these immune cells and interfere its expression in the brain after ischemia, the cerebral ischemia and ischemia-reperfusion injury can be reduced in varying degrees. Research on the effects of immune system on brain injury has made progress. In this paper, the progress of the effects of immune system on brain damage in recent years will be presented.