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J. Dotis,E. Iosifidis, E. Roilides, et al. Central nervous system aspergillosis in children: A systematic review of reported cases. International Journal of Infectious Diseases, 2007, 11(5): 381- 393.


  • 标题: 颅内单纯真菌性肉芽肿1例报告Intracranial Fungal Granuloma: A Case Report

    作者: 康琳敏, 高珊, 罗蓉, 徐炼

    关键字: 颅内真菌性肉芽肿, 曲霉菌, 治疗Intracranial Fungal Granuloma; Aspergillus; Therapy

    期刊名称: 《Asian Case Reports in Pediatrics》, Vol.1 No.2, 2013-05-20

    摘要: 背景:真菌以不同方式和程度累及脑组织、脑膜和颅内血管,其中颅内真菌性肉芽肿(intracranial fungal granuloma, IFG)并不常见,但死亡率高(50%~63%)。国内IFG文献多见于成人病例的个案报道,少见儿童报道。方法:11岁大女性患儿1例,因“反复右枕部疼痛3个月,加重伴呕吐半月”入院,入院查体无异常,MRI提示颅内占位性病变,遂给予手术处理,术后诊断颅内真菌性肉芽肿,并给予术后抗真菌治疗及护理。结果:术后患儿头痛症状消失,至本文投送之日,患儿无临床症状再次出现。结论:手术联合抗真菌治疗IFG仍应作为目前首选治疗方案。 Background: Fungi can intrude into brain, meninges and intracranial blood vessels in different ways, causing several diseases including intracranial fungal granuloma (IFG), which is not common but has a high mortality rate (50% - 63%). Domestic literature about IFG is mostly reported in adult population other than children population. Methods: A 11 year-old female was admitted to the inpatient apartment of pediatrics. The patient showed repeated right occiput pain for more than 3 months, aggravated with vomiting for 15 days. Physical examination on admission revealed no abnormalities. MRI revealed intracranial space-occupying lesions. Then we gave her surgical treatment. The postoperative diagnosis was intracranial fungal granuloma, so that we gave her the antifungal treatment and nursing. Results: The patient showed no more headache ever since the surgery. Until the date of sending out this paper, the patient showed no abnormal clinical manifestations. Conclusion: At present, surgery combined with antifungal therapy should still be considered as the ultimate choice of IFG treatment.