标题:
蛋白去乙酰基酶SIRT1的免疫调节效应及机制Immunomodulation and Mechanism of Protein Deacetylase SIRT1
作者:
张妍, 张正国, 汉丽梅, 刘光伟
关键字:
SIRT1, 巨噬细胞, T细胞, 免疫调节SIRT1; Macrophages; T Cells; Immune Modulation
期刊名称:
《Immunology Studies》, Vol.1 No.2, 2013-11-04
摘要:
机体免疫分为天然免疫和适应性免疫，分别由不同的免疫细胞介导。SIRT1 (silent mating
type information regulation 2 homolog 1)是一种具有烟酰胺腺嘌呤二核苷酸(Nicotinamide Adenine Dinucleotide, NAD)依赖性的蛋白去乙酰基酶活性的转录调节因子，在细胞寿命和机体代谢中发挥重要作用。近年来，SIRT1在免疫中的调控作用逐渐为研究者所重视。本文仅就SIRT1在天然免疫和适应性免疫中的调控效应及分子机制做一简要综述。
Different kinds of lymphocytes could be
involved in the innate immunity and adaptive immunity. Silent mating type
information regulation 2 homolog 1 (SIRT1) is a Nicotinamide Adenine
Dinucleotide (NAD)-dependent protein deacetylase, which plays a critical role
in life span and metabolism. Recently, the immune functional studies of SIRT1
have become a hot spot in immunological field. This review only summarizes the
modulation of SIRT1 on both innate immunity and adaptive immunity and its
molecular mechanism.