常用厨房调味品与P-糖蛋白的相互作用
Interaction between Commonly Used Flavouring in Kitchen and P-Glycoprotein
DOI: 10.12677/HJFNS.2017.63024, PDF, HTML, XML, 下载: 1,569  浏览: 3,183 
作者: 李 杰：淄博职业学院，化学工程系，山东 淄博
关键词: 调味品；P-糖蛋白；姜黄；大蒜；胡椒；辣椒；Flavouring； P-Glycoprotein； Curcuma； Garlic； Pepper； Capsicum Chilli
摘要: 综述常用厨房调味品与P-糖蛋白的相互作用。以“P-糖蛋白、姜黄、生姜、大蒜、胡椒、辣椒”为中文检索词，以“P-Glycoprotein, Curcuma, Curcumine, Fresh Ginger, Garlic, Pepper, Piperine, Capsicum Chilli, Capsicine, Red Pigment”为英文检索词，由第一作者检索Pub Med数据库、Elsevier ScienceDirect、中国知网等数据库中关于常用厨房调味品与P-糖蛋白的相互作用的文章。许多常用厨房调味品存在诱导或抑制P-糖蛋白的作用，所以应该防止日常饮食与药物相互作用时可能发生的风险。
Abstract: To review the interaction between commonly used flavouring in kitchen and P-Glycoprotein. A computer-based retrieval of Pub Med, Elsevier ScienceDirect and CNKI databases was performed for articles concerning the interaction between commonly used flavouring in kitchen and P-Glycoprotein published from 1978 to 2017. The keywords were “P-糖蛋白, 姜黄, 生姜, 大蒜, 胡椒, 辣椒” and “P-Glycoprotein, Curcuma, Curcumine, Fresh Ginger, Garlic, Pepper, Piperine, Capsicum Chilli, Capsicine, Red Pigment” in Chinese and English, respectively. Many commonly used flavouring in kitchen induce or inhibit P-Glycoprotein function. Thus, the possibility of risk between daily diet and drug should be prevented.
文章引用：李杰. 常用厨房调味品与P-糖蛋白的相互作用[J]. 食品与营养科学, 2017, 6(3): 195-199. https://doi.org/10.12677/HJFNS.2017.63024

参考文献

[1] Zhou, S., Lim, L.Y. and Chowbay, B. (2004) Herbal Modulation of P-Glycoprotein. Drug Metabolism Reviews, 36, 57- 104.
https://doi.org/10.1081/DMR-120028427
[2] Ireson, C., Jones, D., Orr, S., Coughtrie, M., Boocock, D., Williams, M., et al. (2002) Metabolism of the Cancer Chemopreventive Agent Curcumin in Human and Rat Intestine. Cancer Epidemiology Biomarkers & Prevention, 11, 105-111.
[3] Sharma, R., McLelland, H., Hill, K., Ireson, C., Euden, S., Manson, M., et al. (2001) Pharmacodynamic and Pharmacokinetic Study of Oral Curcuma Extract in Patients with Colorectal Cancer. Clinic Cancer Research, 7, 1894-900.
[4] Romiti, N., Tongiani, R., Cervelli, F. and Chieli, E. (1998) Effects of Curcumin on P-Glycoprotein in Primary Cultures of Rat Hepatocytes. Life Science, 62, 2349-2358.
https://doi.org/10.1016/S0024-3205(98)00216-1
[5] Anuchapreeda, S., Leechanachai, P., Smith, M., Ambudkar, S. and Limtrakul, P. (2002) Modulation of P-Glycoprotein Expression and Function by Curcumin in Multidrug-Resistant Human KB Cells. Biochemical Pharmacology, 64, 573-582.
https://doi.org/10.1016/S0006-2952(02)01224-8
[6] Limtrakul, P., Anuchapreeda, S. and Buddhasukh, D. (2004) Modulation of Human Multidrug-Resistance MDR-1 Gene by Natural Curcuminoids. BMC Cancer, 17, 13.
https://doi.org/10.1186/1471-2407-4-13
[7] Nabekura, T., Kamiyama, S. and Kitagawa, S. (2005) Effects of Dietary Chemopreventive Photochemical on P-Glycoprotein Function. Biochemical and Biophysical Research Communications, 327, 866-870.
https://doi.org/10.1016/j.bbrc.2004.12.081
[8] 马丽娜, 李峰杰, 陈坚, 李贻奎. 大蒜主要活性成分及药理作用研究进展[J]. 中国药理学通报, 2014, 30(6): 760- 763.
[9] Foster, B., Foster, M., Vandenhoek, S., Krantis, A., Budzinski, J., Arnason, J., et al. (2001) An In Vitro Evaluation of Human Cytochrome P450 3A4 and P-Glycoprotein Inhibition by Garlic. Journal of Pharmacy and Pharmaceutical Sciences, 4, 176-184.
[10] Piscitelli, S., Burstein, A., Chaitt, D., Alfaro, R. and Falloon, J. (2000) Indinavir Concentrations and St. John’ s Wort. Lancet, 355, 547-548.
https://doi.org/10.1016/S0140-6736(99)05712-8
[11] Gallicano, K., Foster, B. and Choudhri, S. (2003) Effect of Short-Term Administration of Garlic Supplements on Single-Dose Ritonavir Pharmacokinetics in Healthy Volunteers. British Journal of Clinical Pharmacology, 55, 199-202.
https://doi.org/10.1046/j.1365-2125.2003.01736.x
[12] Gisolf, E., Heeswijk, R.V., Hoetelmans, R. and Danner, S. (2000) Decreased Exposure to Saquinavir in HIV-1 Infected Patients after Long-Term Antiretroviral Therapy Including Ritonavir and Saquinavir. Aids, 14, 801-805.
https://doi.org/10.1097/00002030-200005050-00005
[13] Laroche, M., Choudhr, S., Gallicano, K. and Foster, B. (1998) Severe Gastrointestinal Toxicity with Concomitant Ingestion of Ritonavir and Garlic. Canadian Journal of Infectious Diseases, 9, 471.
[14] 王颖, 姜子涛, 李荣, 胡耿辉. 黑胡椒和白胡椒精油抗氧化性能及清除自由基能力的比较[J]. 中国调味品, 2009, 34(5): 50-53.
[15] Bhardwaj, R., Glaeser, H., Becquemont, L., Klotz, U., Gupta, S. and Fromm, M. (2002) Piperine, a Major Constituent of Black Pepper, Inhibits Human Pglycoprotein and CYP3A4. Journal of Pharmacology and Experimental Therapeutics, 302, 645-650.
https://doi.org/10.1124/jpet.102.034728
[16] Jensen-Jarolim, E., Gajdzik, L., Haberl, I., Kraft, D., Scheiner, O. and Graf, J. (1998) Hot Spices Influence Permeability of Human Intestinal Epithelial Monolayers. Journal of Nutrition, 128, 577-581.
[17] Velpandian, T., Jasuja, R., Bhardwaj, R., Jaiswal, J. and Gupta, S. (2001) Piperine in Food: Interference in the Pharmacokinetics of Phenytoin. European Journal of Drug Metabolism and Pharmacokinetics, 26, 241-247.
[18] Zutshi, R., Singh, R., Zutshi, U., Johri, R. and Atal, C. (1985) Influence of Piperine on Rifampicin Blood Levels in Patients of Pulmonary Tuberculosis. Journal of the Association of Physicians of India, 33, 223-224.
[19] Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R. and Srinivas, P. (1998) Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers. Planta Medica, 64, 353-356.
https://doi.org/10.1055/s-2006-957450
[20] Han, J. and Isoda, H. (2009) Capsaicin Induced the Upregulation of Transcriptional and Translational Expression of Glycolytic Enzymes Related to Energy Metabolism in Human Intestinal Epithelial Cells. Journal of Agricultural and Food Chemistry, 57, 11148-11153.
https://doi.org/10.1021/jf901943q
[21] Han, Y., Tan, T.M. and Lim, L.Y. (2006) Effects of Capsaicin on P-gp Function and Expression in Caco-2 Cells. Biochemical Pharmacology, 71, 1727-1734.
https://doi.org/10.1016/j.bcp.2006.03.024