灵芝对四氯化碳诱导大鼠慢性肝炎之护肝功效评估
Hepatoprotective Effects of Ganoderma lucidum on Carbon Tetrachloride-Induced Chronic Liver Disease in Rats
DOI: 10.12677/HJFNS.2018.72012, PDF,  被引量   
作者: 邱婕宁, 林定威：葡萄王生技股份有限公司，台湾 桃园；林维莉, 林文川：中国医药大学医学系，台湾 台中；陈劲初：葡萄王生技股份有限公司，台湾 桃园；国立台湾大学食品科技研究所，台湾 台北；实践大学食品营养与保健生技学系，台湾 台北；中原大学生物科技学系，台湾 桃园
关键词: 灵芝；四氯化碳；慢性肝炎；护肝；Ganoderma lucidum； Carbon Tetrachloride； Chronic Liver； Hepatoprotective Effects
摘要: 本试验是以灵芝菌丝体粉及灵芝子实体萃取物制成之灵芝复合品，探讨其对四氯化碳(CCl4)肝炎的功效。四氯化碳(20%、0.2 ml/100g body weight)每星期投予两次，共八星期。大鼠于四氯化碳投予前一天，每日经口头喂予灵芝粉一次，直至实验结束。灵芝产品对第一、三、六、八周四氯化碳所升高的血清AST及ALT值由明显降低作用。四氯化碳诱发大鼠慢性肝炎明显增加脾脏重量，减少肝脏蛋白质含量，增加肝脏脂质过氧化程度及胶原蛋白含量。灵芝产品明显增加蛋白质含量，及降低脂质过氧化程度和胶原蛋白含量。由这些结果明确表示，灵芝粉可以减轻四氯化碳所诱发的大鼠慢性肝炎。
Abstract: The study is based on Ganoderma lucidum mycelium powder and Ganoderma lucidum fruiting body extract made of Ganoderma lucidum powder, to explore its effect on carbon tetrachloride (CCl4) hepatitis. Carbon tetrachloride (20%, 0.2 ml/100g body weight) is administered twice a week for a total of eight weeks. One day prior to the administration of carbon tetrachloride, the rats were orally administered with Ganoderma lucidum orally once daily until the end of the experiment. Ganoderma lucidum powder on the 1, 3, 6, 8 weeks of carbon tetrachloride increased serum AST, and ALT values significantly reduced. Carbon tetrachloride-induced chronic hepatitis in rats significantly increased the weight of the spleen, reduce the liver protein content, increase liver lipid peroxidation and collagen content. Ganoderma lucidum powder significantly increases the protein content, and reduces the degree of lipid peroxidation and collagen content. From these results, it is clear that Ganoderma lucidum powder can alleviate carbon tetrachloride-induced chronic hepatitis in rats.
文章引用：邱婕宁, 林定威, 林维莉, 林文川, 陈劲初. 灵芝对四氯化碳诱导大鼠慢性肝炎之护肝功效评估[J]. 食品与营养科学, 2018, 7(2): 101-109. https://doi.org/10.12677/HJFNS.2018.72012

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