结核分枝杆菌生物膜研究进展
Advances on Research of Mycobacterium tuberculosis Biofilms
DOI: 10.12677/HJMCe.2018.63011, PDF,    国家自然科学基金支持
作者: 甘梦兰*, 王仁凤, 杨再昌：贵州大学药学院，贵州 贵阳
关键词: 结核分枝杆菌；生物膜；耐受性；Mycobacterium tuberculosis； Biofilms； Tolerance
摘要: 生物膜是指被自我产生的细胞外聚合物包裹，并附着在细胞表面的微生物群落，但结核分枝杆菌生物膜的生理学和遗传学定义至今尚未被描述。抗菌药物耐受性通常与之形成的生物膜有关，结核分枝杆菌生物膜因其独特的生理状态，限制了抗结核药物的治疗效果，延长了结核病治疗的周期，严重危害人类健康。该文就结核分枝杆菌生物膜的形成机制、结构成分及相关功能、定量测定方法进行了综述，讨论了以结核分枝杆菌生物膜为靶点新型抗痨药物的研究思路，为缩短结核病治疗时间，提高结核病的治疗效果提供一个新方向。
Abstract: Biofilms refer to a microbial community that is surrounded by a self-generated extracellular po-lymer and attached to the cell surface, but the physiology and genetics definition of the M. tuber-culosis biofilm have not yet been described. Because of its unique physiological state, M. tuberculo-sis biofilms limit the therapeutic effect of anti-tuberculosis drugs, prolong the cycle of tuberculosis treatment, and seriously endanger human health. This article reviewed the formation mechanism, structural composition and related functions and quantitative methods of M. tuberculosis biofilms, and discussed the research ideas of using M. tuberculosis biofilms as novel anti-tuberculosis drugs to shorten the treatment of tuberculosis and provide a new direction for improving the therapeutic effect of tuberculosis.
文章引用：甘梦兰, 王仁凤, 杨再昌. 结核分枝杆菌生物膜研究进展[J]. 药物化学, 2018, 6(3): 78-84. https://doi.org/10.12677/HJMCe.2018.63011

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