牛樟芝菌丝体粉末复方在调节人体血脂之探讨
Evaluation of Blood Lipid-Lowering Effects of Antrodia cinnamomea Mycelia Powder Complex
DOI: 10.12677/HJFNS.2019.81003, PDF,   
作者: 朱心彤：葡萄王生技股份有限公司，台湾 桃园；蔡文城：台美检验科技有限公司，台湾 新北；赵 敞：上海葡萄王企业有限公司，上海；陈劲初：葡萄王生技股份有限公司，台湾 桃园；实践大学食品营养与保健生技学系，台湾 台北；台湾大学食品科技研究所，台湾 台北；中原大学生物科技学系，台湾 桃园
关键词: 高血脂；樟芝菌丝体；低密度脂蛋白胆固醇；Hyperlipidemia； Antrodia cinnamomea； Low Density Lipoprotein Cholesterol
摘要: 本试验系参照卫生署「健康食品之调节血脂功能评估方法」，进行牛樟芝菌丝体粉末复方之血脂调节功能评估试验。募集高胆固醇血症患者(TC > 200 mg/dL)进行人体试验，实验设计分组为服用产品的介入组(Intervention group)以及服用以炒熟面粉代替产品的安慰剂组(Placebo group)，依照产品服用指示一天两次、一次两颗的方式持续两个月。于试验前(观察期, Month 0)以及服用产品或安慰剂一个月(介入一个月, Month 1)、两个月(介入两个月, Month 2)三个时间点抽血检测生化项目，记录受试者基本体位以及饮食纪录。试验期间要求受试者不得更改饮食以及运动的习惯，以达到实验的客观性。实验主要是观察受试者于服用产品前后血清(或血浆)中的血脂指标：三酸甘油酯(Triacylglycerol, TG)、总胆固醇(Cholesterol, TC)、高密度脂蛋白胆固醇(High Density Lipoproteins Cholesterol, HDL-C)和低密度脂蛋白胆固醇(Low Density Lipoprotein Cholesterol, LDL-C)是否有改善。同时也会观察其低密度脂蛋白胆固醇氧化延迟时间(LDL oxidative lag time)是否有因产品介入而延长。另一方面，监控受试者的肝功能指数(Glutamate Oxaloacetate Transaminase, GOT、Glutamic Pyruvic Transaminase, GPT)、肾功能指数(Creatinine, Cr、Blood Urea Nitrogen, BUN)以及空腹血糖来评估产品对人体的影响。在观察期(Month 0)，介入组与安慰剂组间无论在基本体位、饮食习惯以及各项血清(或血浆)生化检测数值均无差别。而受试者开始服用产品或安慰剂后，不论是介入一个月(Month 1)或两个月(Month 2)，均可观察到介入组的总胆固醇(TC)以及低密度脂蛋白胆固醇(LDL-C)相较于观察期(Month 0)有显著的减少，且与同一时间的安慰剂组比较也具有显著性的减少(p < 0.05)，三酸甘油酯(TG)和低密度脂蛋白胆固醇氧化延迟时间(LDL oxidative lag time)则无观察到显著的变化。高密度脂蛋白胆固醇(HDL-C)虽然在组间并无显著差异，但与观察期(Month 0)相比是显著的减少，经计算低密度与高密度脂蛋白胆固醇的比例(LDL-C/HDL-C)，显示相较于高密度胆固醇，低密度胆固醇的下降幅度更显著，因此推测高密度脂蛋白胆固醇是伴随着总胆固醇的减少而减少。根据实验结果，在此人体试验模式下，牛樟芝菌丝体粉末复方具有显著改善血中总胆固醇及低密度脂蛋白胆固醇浓度的功效，有助于降低未来心血管疾病发生风险。
Abstract: Objective: This study was conducted to assess the prenatal developmental blood lipid-lowering effects of an Antrodia cinnamomea mycelia powder complex according to the safety assessment guideline of Health Food announced by Ministry of Health and welfare, Executive Yuan of Taiwan. Methods: A total of 32 hyperlipidemia individuals with TC > 200 mg/dl were randomly divided into intervention group (n = 16) and placebo group (n = 16). Dietary intervention was provided for the intervention group for 2 months. Information on dietary intakes, physical examinations and blood samples was collected. Serum lipids were assayed at baseline and endpoint of the study period. Subjects take two capsules of A. cinnamomea mycelia powder complex or placebo twice a day. The study has 2 weeks run in period, 8 weeks intervention period, and 4 weeks follow-up period. All subjects measure body weight, body fat, blood pressure and biochemical parameters, including triglycerides (TG), total cholesterol (TC), low density lipoprotein in cholesterol (LDL-C), high density lipoprotein in cholesterol (HDL-C), blood sugar, kidney and liver function. Results: The results were found after 8 weeks intervention, the plasma total cholesterol and LDL-C were significantly decreased compared with the initial, and there was significantly difference (p < 0.05) compared with the placebo group. LDL-C/HDL-C and triglyceride level has a decreasing trend. Conclusion: A. cinnamomea mycelia powder complex could decrease blood lipids.
文章引用：朱心彤, 蔡文城, 赵敞, 陈劲初. 牛樟芝菌丝体粉末复方在调节人体血脂之探讨[J]. 食品与营养科学, 2019, 8(1): 17-26. https://doi.org/10.12677/HJFNS.2019.81003

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