血清HCY、ADP在类风湿关节炎患者中的表达及与心血管病变的相关性研究
Expression of Serum HCY and ADP in Patients with Rheumatoid Arthritis and Its Correlation with Cardiovascular Disease
摘要: 目的：探讨血清HCY、ADP在类风湿关节炎患者中的表达及与心血管病变的相关性。方法：选取2018年1月~2019年12月我院收治的类风湿关节炎患者88例作为研究组，根据有无发生心血管疾病分为心血管疾病组(30例)、无心血管疾病组(58例)，同时选取同时间段在我院接受体检的健康人群88例作为对照组。比较研究组与对照组两组人群同型半胱氨酸(HCY)、脂联素(ADP)水平；比较心血管疾病组、无心血管疾病组、对照组HCY、ADP水平；比较研究组治疗前后HCY、ADP水平情况；对比研究组治疗前后疾病活动性评分(DSA28)、C反应蛋白(CRP)、红细胞沉降率(ESR)，并分析血清HCY、ADP在类风湿关节炎患者中的表达与心血管病变的相关性。结果：研究组HCY水平高于对照组(P < 0.05)，研究组ADP水平低于对照组(P < 0.05)；心血管疾病组HCY水平高于无心血管疾病组、对照组(P < 0.05)，心血管疾病组ADP水平低于无心血管疾病组、对照组(P < 0.05)；研究组治疗后HCY水平低于治疗前(P < 0.05)，研究组治疗后ADP水平高于治疗前(P < 0.05)；研究组治疗后DSA28、CRP、ESR低于治疗前(P < 0.05)；血清HCY在类风湿关节炎患者中的表达与心血管病变的数量呈正相关(P < 0.05)，ADP水平在类风湿关节炎患者中的表达与心血管病变的数量呈负相关(P < 0.05)。结论：血清HCY在类风湿关节炎患者中表达水平显著升高，ADP水平在类风湿关节炎患者中表达水平显著降低，且HCY、ADP在类风湿关节炎患者中的表达与心血管病变存在明显的关系，及时给予患者治疗可以改善HCY、ADP水平。
Abstract: Objective: To investigate the expression of serum HCY and ADP in patients with rheumatoid arthritis and its correlation with cardiovascular disease. Methods: A total of 88 patients with rheumatoid arthritis admitted to our hospital from January 2018 to December 2019 were selected as the research group. They were divided into a cardiovascular disease group (30 cases) and a cardiovascular disease-free group (58 cases) according to the occurrence of cardiovascular disease. At the same time, 88 healthy people who received physical examination in our hospital at the same time were selected as the control group. Homocysteine (HCY) and adiponectin (ADP) levels were compared between the study group and the control group. The levels of HCY and ADP in the cardiovascular disease group, the non-cardiovascular disease group and the control group were compared. The levels of HCY and ADP before and after treatment in the study group were compared. Disease activity score (DSA28), c-reactive protein (CRP), erythrocyte sedimentation rate (ESR) were compared before and after treatment in the study group, and the correlation between serum HCY and ADP expression in patients with rheumatoid arthritis and cardiovascular diseases was analyzed. Results: The HCY level of the study group was higher than that of the control group (P < 0.05), and the ADP level of the study group was lower than that of the control group (P < 0.05); the HCY level of the cardiovascular disease group was higher than that of the non-cardiovascular disease group and the control group (P < 0.05); the ADP level of the cardiovascular disease group was lower than that of the non-cardiovascular disease group and the control group (P < 0.05); the HCY level of the study group after treatment was lower than before treatment (P < 0.05), and the ADP level of the study group after treatment was higher than before treatment (P < 0.05); DSA28, CRP, and ESR in the study group were lower than before treatment (P < 0.05); the expression of serum HCY in patients with rheumatoid arthritis was positively correlated with the number of cardiovascular diseases (P < 0.05), and the expression of ADP level in patients with rheumatoid arthritis was negatively correlated with the number of cardiovascular diseases (P < 0.05). Conclusion: The expression level of serum HCY is significantly increased in patients with rheumatoid arthritis, the expression level of ADP is significantly reduced in patients with rheumatoid arthritis, and the expression of HCY and ADP in patients with rheumatoid arthritis has a significant relationship with cardiovascular disease. Treating patients can improve HCY and ADP levels.
文章引用：刘莹爽, 李静. 血清HCY、ADP在类风湿关节炎患者中的表达及与心血管病变的相关性研究[J]. 临床医学进展, 2020, 10(5): 761-767. https://doi.org/10.12677/ACM.2020.105117

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