钠钙交换体与心肌缺血/再灌注性心律失常
Sodium Calcium Exchanger and Myocardial Ischemia/Reperfusion Arrhythmia
DOI: 10.12677/HJMCe.2022.104038, PDF,    科研立项经费支持
作者: 陈依春：西藏民族大学藏药检测技术教育部工程研究中心，陕西 咸阳
关键词: 缺血/再灌注损伤；心律失常；NCX；Ischemia/Reperfusion Injury； Arrhythmia； NCX
摘要: 钠–钙交换体(Na+/Ca2+ exchanger, NCX)是维持心肌细胞钙稳态的重要结构，与心肌正常电活动和收缩、舒张密切相关。在心肌缺血/再灌注性心律失常的发生过程中，NCX活动增强并参与了心肌细胞钙超载的诱发。近年来随着人们对NCX研究的不断深入以及新型工具药的研发和应用，抑制心肌钠–钙交换活动有望成为今后干预心肌缺血/再灌注性心律失常的新方向和新途径。
Abstract: Na+/Ca2+ exchanger (NCX) is an important structure to maintain calcium homeostasis in cardiomyocytes, which is closely related to normal electrical activity, contraction and relaxation of myocardium. During the occurrence of myocardial ischemia/reperfusion arrhythmias, NCX activity is enhanced and participates in the induction of calcium overload in cardiomyocytes. In recent years, with the continuous deepening of NCX research and the development and application of new tool drugs, inhibiting myocardial sodium calcium exchange activity is expected to become a new direction and new way to intervene myocardial ischemia/reperfusion arrhythmia in the future.
文章引用：陈依春. 钠钙交换体与心肌缺血/再灌注性心律失常[J]. 药物化学, 2022, 10(4): 358-362. https://doi.org/10.12677/HJMCe.2022.104038

参考文献

[1] 胡盛寿. 中国心血管病报告[M]. 北京: 中国大百科全书出版社, 2015: 11-15.
[2] 姚震, 陈林. 我国心血管疾病的现状与展望[J]. 海南医学, 2013, 13(24): 1873-1876.
[3] Goldhaber, J.I. and Philipson, K.D. (2013) Cardiac So-dium-Calcium Exchange and Efficient Excitation-Contraction Coupling: Implications for Heart Disease. Advances in Ex-perimental Medicine and Biology, 961, 355-364.
[4] 刘秀华. 钠钙交换体与心肌缺血再灌注[J]. 中国动脉硬化杂志, 2005, 13(2): 233-235.
[5] 沈磊, 吴玉林. 钠钙交换体及其抑制剂在心律失常中的作用[J]. 中国临床药理学与治疗学, 2006, 11(6): 610-613.
[6] Hayashi, R., et al. (2011) Heart Disease and Stroke Statistics—2011 Update: A Report from the American Heart Association. Circulation, 124, e18-e209.
[7] Karacueusian, H.S. and Katzung, B.G. (1982) Voltage-Clamp Studies of Transient Inward Current and Mechanical Oscillations Induced by Ouabain in Ferret Papillary Muscle. The Journal of Physiology, 327, 255-271. [Google Scholar] [CrossRef] [PubMed]
[8] 高亚男. 抗Na+/Ca2+交换体α-2(840-877)单克隆抗体的制备及其对大鼠心室肌细胞Na+/Ca2+交换电流的特异性抑制作用研究[D]: [硕士学位论文]. 太原: 山西医科大学, 2014.
[9] 邹操. 钙循环与心力衰竭[J]. 心血管病学进展, 2007, 28(2): 266-268.
[10] Ian, S.C. and Sham, J.S.K. (2003) Effects of Na/Ca Exchange Induced by SR Ca Release on Action Potentials and after Depolarizations in Guinea Pig Ventricular Myocytes. The American Journal of Physiology-Heart and Circulatory Physiology, 285, H2552-H2562. [Google Scholar] [CrossRef] [PubMed]
[11] Bögeholz, N., Pauls, P., Bauer, B.K., Schulte, J.S., et al. (2015) Suppression of Early and Late after Depolarizations by Heterozygous Knockout of the Na+/Ca2+ Exchanger in a Murine Model. Circulation: Arrhythmia and Electrophysiology, 8, 1210-1218. [Google Scholar] [CrossRef] 
[12] 李志强. 缺血再灌注心律失常机制探讨[J]. 国外医学麻醉学与复苏分册, 2001, 22(5): 303.
[13] 王雅锋. 钠钙和钠氢交换蛋白与心肌缺血再灌注损伤[J]. 医学综述, 2007, 13(5): 368-370.
[14] 张轩萍, 牛栓成, 张明升, 等. KB-R7943对大鼠离体心脏缺血/再灌注的后适应保护作用[J]. 中国药理学通报, 2008, 24(4): 522-525.
[15] Satoh, N. and Kitada, Y. (2004) Cardioprotective Effect of MCC-135 Is Associated with Inhibition of Ca2+ Overload in Ischemic/Reperfused Hearts. European Journal of Pharmacology, 499, 179-187. [Google Scholar] [CrossRef] [PubMed]