细菌群体感应机制的动力学建模研究
The Dynamical Modeling Studies of the Quorum Sensing Mechanism in Bacteria
DOI: 10.12677/BIPHY.2018.62002, PDF,    国家自然科学基金支持
作者: 张晓翠, 李 翔, 刘艳平, 吴宇宁, 帅建伟*：厦门大学，物理科学与技术学院，物理系，福建 厦门；黄世阳, 王兆守：厦门大学，化学化工学院，化学工程与生物工程系，生物化工研究所，福建 厦门
关键词: 群体感应；信号分子；信号网络；基因调控；细菌；动力学建模；Quorum Sensing； Signal Molecule； Signal Network； Gene Regulation； Bacteria； Dynamic Modeling
摘要: 群体感应是细菌之间的信号交流，可以通过监控自身群体密度来调控细菌许多重要生物学功能。目前人们主要通过实验和数学建模两种方法来研究群体感应机制，细菌的群体感应信号通路虽然非常复杂，但我们可以通过对关键蛋白的信号网络进行建模，定量研究细菌群体感应核心信号通路的动力学调控机理。本文总结介绍了野生细菌中和人工合成细菌中的群体感应信号网络系统模型，其中野生细菌群体中的群体感应系统包括革兰氏阴性菌、革兰氏阳性菌、革兰氏阳性菌和阴性菌共有的群体感应系统三类，我们分别详细讨论了几种具有代表性的细菌中群体感应系统的各种信号网络动力学建模方法及其动力学调控研究进展，也对未来进一步的建模研究进行了展望。
Abstract: Quorum sensing is a signal exchange between bacteria, which can regulate many important bio-logical functions of bacteria by monitoring their population density. At present researchers study the quorum sensing mechanisms mainly with experiment or mathematical modeling. The quorum sensing signaling pathways of bacteria are extremely complex, but theoretically we can focus on the signaling network modeling of key proteins to quantitatively discuss the dynamical mechanisms of bacterial quorum sensing. This paper reviews the research progress of bacterial quorum sensing network modeling both in the wild bacteria and artificial synthesis bacteria, including Gramnegative bacteria, Grampositive bacteria and the bacteria which both have Gramnegative and Grampositive quorum sensing systems. The various dynamical modeling methods of the quorum sensing systems and their regulation mechanism are discussed in details. Open questions for future modeling are also suggested and prospected.
文章引用：张晓翠, 黄世阳, 李翔, 刘艳平, 吴宇宁, 帅建伟, 王兆守. 细菌群体感应机制的动力学建模研究[J]. 生物物理学, 2018, 6(2): 7-30. https://doi.org/10.12677/BIPHY.2018.62002

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