大黄酸衍生物的合成及生物活性研究进展
Research Progress on Synthesis and Biological Activity of Rhubarb Acid Derivatives
DOI: 10.12677/HJMCe.2018.62005, PDF,    国家自然科学基金支持
作者: 缪丽, 王文龙*：江南大学药学院，江苏 无锡
关键词: 大黄酸衍生物；合成；生物活性评价；Rhein Derivatives； Synthesis； Biological Evaluation
摘要: 大黄酸是中药芦荟、大黄的有效成分之一，含有平面状的1,8-二羟基蒽醌结构单元，存在溶解度差、生物利用度低等问题。为了改善其理化性质，提高生物利用度，发现新的适应症，国内外学者围绕大黄酸衍生物做了深入研究。本文简要综述了大黄酸衍生物的合成及其在降血糖、消炎以及抗肿瘤等方面的生物活性研究进展。
Abstract: Rhein is one of the active ingredients of traditional Chinese medicine aloe and rhubarb, and contains planar 1,8-dihydroxy anthraquinone structural units, with poor solubility and low bioavailability. In order to improve its physical and chemical properties, improve bioavailability and find new indications, domestic and foreign scholars have conducted in-depth studies on rhein derivatives. This article briefly reviewed the synthesis of rhein derivatives and their biological activities in reducing blood sugar, anti-inflammatory and anti-tumor.
文章引用：缪丽, 王文龙. 大黄酸衍生物的合成及生物活性研究进展[J]. 药物化学, 2018, 6(2): 29-36. https://doi.org/10.12677/HJMCe.2018.62005

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